Endogenous neurogenesis in adult mammals after spinal cord injury

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• 作者：Hongmei Duan ; Wei Song ; Wen Zhao ; Yudan Gao ; Zhaoyang Yang…
• 关键词：adult endogenous neurogenesis ; neural stem cells ; ependymal cells ; spinal cord injury ; adult mammals ; regeneration
• 刊名：Science China Life Sciences
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：59
• 期：12
• 页码：1313-1318
• 全文大小：379KB
• 刊物主题：Life Sciences, general;
• 出版者：Science China Press
• ISSN：1869-1889
• 卷排序：59

文摘

During the whole life cycle of mammals, new neurons are constantly regenerated in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles. Thanks to emerging methodologies, great progress has been made in the characterization of spinal cord endogenous neural stem cells (ependymal cells) and identification of their role in adult spinal cord development. As recently evidenced, both the intrinsic and extrinsic molecular mechanisms of ependymal cells control the sequential steps of the adult spinal cord neurogenesis. This review introduces the concept of adult endogenous neurogenesis, the reaction of ependymal cells after adult spinal cord injury (SCI), the heterogeneity and markers of ependymal cells, the factors that regulate ependymal cells, and the niches that impact the activation or differentiation of ependymal cells.