Effect of early intensive insulin therapy on immune function of aged patients with severe trauma
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  • 作者:Junxun Ma (1)
    Xiaodong Zhao (1)
    Qin Su (1)
    Wei Dang (1)
    Xian Zhang (1)
    Xiaoling Yuan (1)
    Jianbo Zhang (1)
    Hongsheng Liu (1)
    Yuhong Qin (1)
    Yongming Yao (1)
    Hong Shen (2)
  • 关键词:trauma ; the elderly ; immune function ; T lymphocyte subsets ; Th1/Th2 ratio ; CD14+ monocyte human leukocyte antigen DR
  • 刊名:Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 出版年:2012
  • 出版时间:June 2012
  • 年:2012
  • 卷:32
  • 期:3
  • 页码:400-404
  • 全文大小:384KB
  • 参考文献:1. Koskenkari JK, Kaukoranta PK, Rimpilinen J, / et al. Anti-inflammatory effect of high-dose insulin treatment after urgent coronary revascularization surgery. Acta Anaesthesiol Scand, 2006,50:962-69 CrossRef
    2. Van den Berghe G. Insulin therapy in the intensive care unit should be targeted to maintain blood glucose between 4.4 mmol/L and 6.1 mmol/L. Diabetologia, 2008,51(6): 911-15 CrossRef
    3. Van den Berghe G, Wilmer A, Hermans G, / et al. Intensive insulin therapy in the medical ICU. N Engl J Med, 2006, 354(5):449-61 CrossRef
    4. Van den Berghe G, Wilmer A, Milants I, / et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes, 2006,55(11): 3151-159 CrossRef
    5. Van den Berghe G, Schoonheydt K, Becx P, / et al. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology, 2005,64(8): 1348-353 CrossRef
    6. Zhao XD. Posttraumatic insulin resistance and blood glucose control. Chin Crit Care Med (Chinese), 2006,18(12): 766-68
    7. Zhao XD, Yao YM, Ma JX, / et al. Effects of intensive insulin therapy on serum immunoglobulin, complement levels and phagocytosis of monocytes in patients with severe trauma. Chin Crit Care Med (Chinese), 2007,19(5): 279-82
    8. Flohe S, Lendemans S, Schade FU, / et al. Influence of surgical intervention in the immune response of severely injured patients. Intensive Care Med, 2004;30(1):96-02 CrossRef
    9. Aldawood AS, Tamim HM, Alsultan MA, / et al. Intensive insulin therapy versus conventional insulin therapy for critically ill trauma patients admitted to ICU. Middle East J Anesthesiol, 2010,20(5):659-66
    10. Miller RS, Norris PR, Jenkins JM, / et al. Systems initia tives reduce healthcare-associated infections: a study of 22,928 device days in a single trauma unit. J Trauma, 2010,68(1):23-1 CrossRef
    11. Wright K, Nwariaku F, Halaihel N, / et al. Bum-activated neutrophils and tumor necrosis factor-alpha alter endothelial cell actin cytoskeleton and enhance monolayer permeability. Surgery, 2000,128(2):259-65 CrossRef
    12. Cheng M, Wu J, Li Y, / et al. Activation of MAPK participates in low shear stress-induced IL-8 gene expression in endothelial cells. Clin Biomech (Bristol, Avon), 2008, 23(Suppl 1):S96–S103 CrossRef
    13. Marti HJ, Bernaudin M, Bellail A, / et al. Hypoxia induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol, 2000,156(3):965-76. CrossRef
    14. Shore PM, Jacknon CK, Wisniewski SR, / et al. Vascular endothelial growth factor is increased in cerebrospinalfluid after traumatic brain injury in infants and children. Neurosurgery, 2004,54(3):605-11 CrossRef
    15. Eakins J. Blood glucose control in the trauma patient. J Diabetes Sci Technol, 2009,3(6):1373-376
    16. Hershman MJ, Cheadle WG, Wellhausen SR, / et al. Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg, 1990, 77(2):204-07 CrossRef
    17. Heinzelmann M, Mercer-Jones M, Cheadle WG, / et al. CD14 expression in injured patients correlates with outcome. Ann Surg, 1996,224(1):91-6 CrossRef
    18. Ditschkowski M, Kreuzfelder E, Rebmann V, / et al. HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Ann Surg, 1999,229(2):246-54 CrossRef
    19. Ellger B, Debaveye Y, Vanhorebeek I, / et al. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemiaindependent actions of insulin. Diabetes, 2006,55(4): 1096-105 CrossRef
  • 作者单位:Junxun Ma (1)
    Xiaodong Zhao (1)
    Qin Su (1)
    Wei Dang (1)
    Xian Zhang (1)
    Xiaoling Yuan (1)
    Jianbo Zhang (1)
    Hongsheng Liu (1)
    Yuhong Qin (1)
    Yongming Yao (1)
    Hong Shen (2)

    1. Department of Emergency, the First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, 100048, China
    2. Department of Emergency, the Chinese PLA General Hospital, Beijing, 100853, China
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