Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis

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• 作者：Aamir A. Khan ; Terence J. Quinn ; Jonathan Hewitt ; Yuhua Fan ; Jesse Dawson
• 关键词：Uric acid ; Dementia ; Cognition ; Systematic review ; Meta ; analysis
• 刊名：AGE
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：38
• 期：1
• 全文大小：1,374 KB
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• 作者单位：Aamir A. Khan (1)
  Terence J. Quinn (2)
  Jonathan Hewitt (3)
  Yuhua Fan (4)
  Jesse Dawson (2)
  
  1. School of Medicine, University of Glasgow, Glasgow, UK
  2. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
  3. Department of Geriatric Medicine, Institute of Primary Care and Public Health, Cardiff University, Cardiff, UK
  4. Department of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department, National Key Discipline, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Geriatrics and Gerontology
  Molecular Medicine
  
• 出版者：Springer Netherlands
• ISSN：1574-4647

文摘

Serum uric acid (sUA) level may be associated with cognitive impairment/dementia. It is possible this relationship varies with dementia subtype, particularly between vascular dementias (VaD) and Alzheimer’s (AD) or Parkinson’s disease (PDD)-related dementia. We aimed to present a synthesis of all published data on sUA and relationship with dementia/cognition through systematic review and meta-analysis. We included studies that assessed the association between sUA and any measure of cognitive function or a clinical diagnosis of dementia. We pre-defined subgroup analyses for patients with AD, VaD, PDD, mild cognitive impairment (MCI), and mixed or undifferentiated. We assessed risk of bias/generalizability, and where data allowed, we performed meta-analysis to describe pooled measures of association across studies. From 4811 titles, 46 papers (n = 16,688 participants) met our selection criteria. Compared to controls, sUA was lower in dementia (SDM −0.33 (95%CI)). There were differences in association by dementia type with apparent association for AD (SDM −0.33 (95%CI)) and PDD (SDM −0.67 (95%CI)) but not in cases of mixed dementia (SDM 0.19 (95%CI)) or VaD (SDM −0.05 (95%CI)). There was no correlation between scores on Mini-Mental State Examination and sUA level (summary r 0.08, p = 0.27), except in patients with PDD (r 0.16, p = 0.003). Our conclusions are limited by clinical heterogeneity and risk of bias in studies. Accepting this caveat, the relationship between sUA and dementia/cognitive impairment is not consistent across all dementia groups and in particular may differ in patients with VaD compared to other dementia subtypes. Keywords Uric acid Dementia Cognition Systematic review Meta-analysis