Parametric imaging using contrast-enhanced ultrasound with Sonazoid for hepatocellular carcinoma

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• 作者：Manabu Watanabe (1)
  Kazue Shiozawa (1)
  Masayoshi Takahashi (1)
  Noritaka Wakui (1)
  Yuichiro Otsuka (2)
  Hironori Kaneko (2)
  Kayoko Tanikawa (3)
  Kazutoshi Shibuya (3)
  Naohisa Kamiyama (4)
  Yasukiyo Sumino (1)
  
• 关键词：Contrast ; enhanced ultrasound ; Sonazoid ; Parametric image ; Time ; intensity curve ; Hepatocellular carcinoma
• 刊名：Journal of Medical Ultrasonics
• 出版年：2010
• 出版时间：April 2010
• 年：2010
• 卷：37
• 期：2
• 页码：81-86
• 全文大小：432KB
• 参考文献：1. Hatanaka K, Kudo M, Minami Y, et al. Differential diagnosis of hepatic tumors: value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid. Intervirology. 2008;51:61-. CrossRef
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  3. Luo W, Numata K, Morimoto M, et al. Three-dimensional contrast-enhanced sonography of vascular patterns of focal liver tumors: pilot study of visualization methods. AJR Am J Roentgenol. 2009;192:165-3. CrossRef
  4. Shiozawa K, Watanabe M, Sumino Y. Evaluation of the hemodynamic status of focal hepatic lesions 20?mm or less in diameter by contrast-enhanced ultrasonography using Sonazoid. Intervirology. 2009;52:213-2. CrossRef
  5. Sugimoto K, Moriyasu F, Kamiyama N, et al. Correlation between parametric imaging using contrast ultrasound and the histological differentiation of hepatocellular carcinoma. Hepatol Res. 2007;38:273-0. CrossRef
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• 作者单位：Manabu Watanabe (1)
  Kazue Shiozawa (1)
  Masayoshi Takahashi (1)
  Noritaka Wakui (1)
  Yuichiro Otsuka (2)
  Hironori Kaneko (2)
  Kayoko Tanikawa (3)
  Kazutoshi Shibuya (3)
  Naohisa Kamiyama (4)
  Yasukiyo Sumino (1)
  
  1. Department of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6-11-1, Omorinishi, Ota-ku, Tokyo, 143-8541, Japan
  2. Department of Hepato-Biliary-Pancreatic Surgery, Toho University Medical Center, Omori Hospital, 6-11-1, Omorinishi, Ota-ku, Tokyo, 143-8541, Japan
  3. Department of Surgical Pathology, Toho University Medical Center, Omori Hospital, 6-11-1, Omorinishi, Ota-ku, Tokyo, 143-8541, Japan
  4. The Ultrasound Systems Development Department, Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan
  

文摘

Purpose To clarify the usefulness of parametric imaging using contrast-enhanced ultrasound (CE-US) with Sonazoid by comparing parametric images of hepatocellular carcinoma (HCC) with histopathological findings. Methods Two patients with HCCs underwent CE-US with Sonazoid before surgical resection. A single focus point was set at the lower margin of the tumor, and a bolus intravenous injection of Sonazoid (0.5?ml) was administered. Images of the ideal scanning plane were displayed in real-time mode for the early vascular phase. We analyzed these images using prototype PC software. The software watches, pixel by pixel, the increase in the intensity due to the inflow of the microbubbles, and displays colors if the intensity becomes larger than a certain threshold. Parametric images were compared with histopathological findings. Results The level of blood flow in the tumor could be visually evaluated using a single image by expressing the detailed hemodynamics of the tumor in terms of differences in color using a time axis appropriate for each case. Conclusions Parametric imaging is a very useful way of facilitating straightforward visualization of the level of blood flow within HCC and the distribution of histopathological findings in single static images.