Serine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma

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• 作者：Xinglong Zhi ; Hongqi Zhang ; Chuan He ; Yukui Wei…
• 关键词：Glioma ; PPP5C ; Proliferation ; Migration
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：35
• 期：5
• 页码：669-677
• 全文大小：2,233 KB
• 参考文献：Camps M, Nichols A, Arkinstall S (2000) Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J 14(1):6鈥?6PubMed
  Chen MS, Silverstein AM, Pratt WB, Chinkers M (1996) The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J Biol Chem 271(50):32315鈥?2320PubMed View Article
  Cohen P (2001) The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur J Biochem 268(19):5001鈥?010PubMed View Article
  Davies TH, Ning YM, Sanchez ER (2005) Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506. Biochemistry 44(6):2030鈥?038. doi:10.鈥?021/鈥媌i048503v PubMed View Article
  Ferguson HA, Marietta PM, Van Den Berg CL (2003) UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance. J Biol Chem 278(46):45793鈥?5800. doi:10.鈥?074/鈥媕bc.鈥婱307979200 PubMed View Article
  Fukuda H, Tsuchiya N, Hara-Fujita K, Takagi S, Nagao M, Nakagama H (2007) Induction of abnormal nuclear shapes in two distinct modes by overexpression of serine/threonine protein phosphatase 5 in Hela cells. J Cell Biochem 101(2):321鈥?30. doi:10.鈥?002/鈥媕cb.鈥?1178 PubMed View Article
  Ghobrial IM, McCormick DJ, Kaufmann SH, Leontovich AA, Loegering DA, Dai NT, Krajnik KL, Stenson MJ, Melhem MF, Novak AJ, Ansell SM, Witzig TE (2005) Proteomic analysis of mantle-cell lymphoma by protein microarray. Blood 105(9):3722鈥?730. doi:10.鈥?182/鈥媌lood-2004-10-3999 PubMed Central PubMed View Article
  Golden T, Aragon IV, Zhou G, Cooper SR, Dean NM, Honkanen RE (2004) Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice. Cancer Lett 215(1):95鈥?00. doi:10.鈥?016/鈥媕.鈥媍anlet.鈥?004.鈥?3.鈥?27 PubMed View Article
  Golden T, Aragon IV, Rutland B, Tucker JA, Shevde LA, Samant RS, Zhou G, Amable L, Skarra D, Honkanen RE (2008a) Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. Biochim Biophys Acta 1782(4):259鈥?70. doi:10.鈥?016/鈥媕.鈥媌badis.鈥?008.鈥?1.鈥?04 PubMed Central PubMed View Article
  Golden T, Swingle M, Honkanen RE (2008b) The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer. Cancer Metastasis Rev 27(2):169鈥?78. doi:10.鈥?007/鈥媠10555-008-9125-z PubMed Central PubMed View Article
  Guo W, Zhang Y, Chen T, Wang Y, Xue J, Zhang Y, Xiao W, Mo X, Lu Y (2011) Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model. J Cancer Res Clin Oncol 137(1):65鈥?2. doi:10.鈥?007/鈥媠00432-010-0860-5 PubMed View Article
  Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H, Houghton PJ (2003) Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell 11(6):1491鈥?501PubMed View Article
  Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ (2004) Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. J Biol Chem 279(35):36490鈥?6496. doi:10.鈥?074/鈥媕bc.鈥婱401208200 PubMed View Article
  Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ (2005) Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol 23(2):222鈥?26. doi:10.鈥?038/鈥媙bt1051 PubMed View Article
  Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumours. Brain Pathol 3(3):255鈥?68PubMed View Article
  Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61(3):215鈥?25 discussion 226鈥?19PubMed
  Kutuzov MA, Andreeva AV, Voyno-Yasenetskaya TA (2005) Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5. J Biol Chem 280(27):25388鈥?5395. doi:10.鈥?074/鈥媕bc.鈥婱413202200 PubMed Central PubMed View Article
  Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114(2):97鈥?09. doi:10.鈥?007/鈥媠00401-007-0243-4 PubMed Central PubMed View Article
  Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H (2002) Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid Redox Signal 4(3):415鈥?25. doi:10.鈥?089/鈥?523086026019621鈥? PubMed View Article
  Mkaddem SB, Werts C, Goujon JM, Bens M, Pedruzzi E, Ogier-Denis E, Vandewalle A (2009) Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells. J Biol Chem 284(18):12541鈥?2549. doi:10.鈥?074/鈥媕bc.鈥婱808376200 PubMed Central PubMed View Article
  Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (2001) Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J 20(21):6028鈥?036. doi:10.鈥?093/鈥媏mboj/鈥?0.鈥?1.鈥?028 PubMed Central PubMed View Article
  Mumby MC, Walter G (1993) Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Physiol Rev 73(4):673鈥?99PubMed
  Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, Stroup NE, Kruchko C, Barnholtz-Sloan JS (2013) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006鈥?010. Neuro Oncol 15(Suppl 2):ii1鈥搃i56. doi:10.鈥?093/鈥媙euonc/鈥媙ot151 PubMed Central PubMed View Article
  Shirato H, Shima H, Nakagama H, Fukuda H, Watanabe Y, Ogawa K, Matsuda Y, Kikuchi K (2000) Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene. Int J Oncol 17(5):909鈥?12PubMed
  Silverstein AM, Galigniana MD, Chen MS, Owens-Grillo JK, Chinkers M, Pratt WB (1997) Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J Biol Chem 272(26):16224鈥?6230PubMed View Article
  Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, European Organisation for R, Treatment of Cancer Brain T, Radiotherapy G, National Cancer Institute of Canada Clinical Trials G (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987鈥?96. doi:10.鈥?056/鈥婲EJMoa043330 PubMed View Article
  Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE (2003) Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression. J Biol Chem 278(11):9747鈥?753. doi:10.鈥?074/鈥媕bc.鈥婱210993200 PubMed View Article
  Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH (2008) Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell 31(6):886鈥?95. doi:10.鈥?016/鈥媕.鈥媘olcel.鈥?008.鈥?7.鈥?21 PubMed Central PubMed View Article
  Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ, Wabl M (2004) DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci USA 101(5):1247鈥?252. doi:10.鈥?073/鈥媝nas.鈥?307765100 PubMed Central PubMed View Article
  Zhang ZY (2002) Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development. Annu Rev Pharmacol Toxicol 42:209鈥?34. doi:10.鈥?146/鈥媋nnurev.鈥媝harmtox.鈥?2.鈥?83001.鈥?44616 PubMed View Article
  Zhang J, Bao S, Furumai R, Kucera KS, Ali A, Dean NM, Wang XF (2005) Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Mol Cell Biol 25(22):9910鈥?919. doi:10.鈥?128/鈥婱CB.鈥?5.鈥?2.鈥?910-9919.鈥?005 PubMed Central PubMed View Article
  Zhou G, Golden T, Aragon IV, Honkanen RE (2004) Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. J Biol Chem 279(45):46595鈥?6605. doi:10.鈥?074/鈥媕bc.鈥婱408320200 PubMed View Article
  Zuo Z, Dean NM, Honkanen RE (1998) Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest. J Biol Chem 273(20):12250鈥?2258PubMed View Article
  Zuo Z, Urban G, Scammell JG, Dean NM, McLean TK, Aragon I, Honkanen RE (1999) Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest. Biochemistry 38(28):8849鈥?857. doi:10.鈥?021/鈥媌i990842e PubMed View Article
  
• 作者单位：Xinglong Zhi (1)
  Hongqi Zhang (1)
  Chuan He (1)
  Yukui Wei (1)
  Lisong Bian (1)
  Guilin Li (1)
  
  1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830

文摘

Glioma is the most common type of primary central nervous system tumor. Ser/Thr protein phosphatase 5 (PP5) has been shown to regulate multiple signaling cascades that suppress growth and facilitate apoptosis in several human cancer cells. However, the role of PP5 in human gliomas remains unclear. Herein, the relationship between PP5 expression and glioma cell growth was investigated, and the therapeutic value of PP5 in glioma was further evaluated. We employed a short hairpin RNA targeting PPP5C gene to knock down PP5 expression in human glioma cell lines U251 and U373. Depletion of PPP5C via RNAi remarkably inhibited glioma cell proliferation and colony formation, and arrested cell cycle in the G0/G1 phase. Moreover, knockdown of PP5 markedly suppressed glioma cell migration, as determined by Transwell assay. Our findings suggest that PPP5C could be essential for glioma cell growth and serve as a promising therapeutic target in human gliomas.