Metabolomic analysis of amino acid and fat metabolism in rats with l-tryptophan supplementation
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- 作者：Zheng Ruan (1)
Yuhui Yang (1)
Yanmei Wen (1)
Yan Zhou (1)
Xiaofang Fu (2)
Sheng Ding (3)
Gang Liu (4)
Kang Yao (4)
Xin Wu (4)
Zeyuan Deng (1)
Guoyao Wu (5)
Yulong Yin (1) (4) - 关键词：Tryptophan ; Animo acids ; Metabolism ; Metabolomic ; Nuclear magnetic resonance spectroscopy
- 刊名：Amino Acids
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：46
- 期：12
- 页码：2681-2691
- 全文大小：1,287 KB
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Gang Liu (4)
Kang Yao (4)
Xin Wu (4)
Zeyuan Deng (1)
Guoyao Wu (5)
Yulong Yin (1) (4)
1. State Key Laboratory of Food Science and Technology, College of Life Science and Food Engineering, Nanchang University, Rm325, 235 Nanjing Street, Nanchang, 330047, China
2. Analytic Center for Hubei Entry-Exit Inspection and Quarantine Bureau, Wuhan, 430031, China
3. Institute of Nutrition and Food Safety, Center for Disease Control and Prevention of Jiangxi Province, Nanchang, 330029, China
4. Hunan Engineering and Research Center of Animal and Poultry Science, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China
5. Department of Animal Science, Faculty of Nutrition, Texas A&M University, College Station, TX, 77843-2471, USA - ISSN：1438-2199
文摘
Tryptophan (TRP) is an important precursor for several neurotransmitters and metabolic regulators, which play a vital role in regulating nutrient metabolism. The purpose of this study was to investigate the effects of tryptophan supplementation on the biochemical profiles, intestinal structure, liver structure and serum metabolome in rats. Rats received daily intragastric administration of either tryptophan at doses of 200?mg/kg body weight per day or saline (control group) for 7?days. TRP supplementation had a tendency to decrease the body weight of rats (P?>?0.05). The levels of urea and CHO in serum were decreased in the TRP-supplemented group rats compared with control group rats (P?P?