Bisphenol A Does Not Affect Memory Performance in Adult Male Rats
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- 作者：Rika Kuwahara (1)
Shinichiro Kawaguchi (1)
Yumi Kohara (2)
Takeshi Jojima (2)
Kimihiro Yamashita (3) - 关键词：Bisphenol A ; Endocrine disruptors ; Oral administration ; Memory ; Hippocampus
- 刊名：Cellular and Molecular Neurobiology
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：34
- 期：3
- 页码：333-342
- 全文大小：584 KB
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Shinichiro Kawaguchi (1)
Yumi Kohara (2)
Takeshi Jojima (2)
Kimihiro Yamashita (3)
1. Graduate School of Science and Technology, Nagasaki University, Nagasaki, 852-8521, Japan
2. Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki, 852-8521, Japan
3. Division of Environmental Chemistry and Ecotoxicology, Institute of Environmental Studies, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki, 852-8521, Japan - ISSN：1573-6830
文摘
Bisphenol A (BPA) is an estrogenic endocrine disruptor used for producing polycarbonate plastics and epoxy resins. This study investigated the effects of oral BPA administration on memory performance, general activity, and emotionality in adult male Sprague Dawley rats using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) used to assess spatial memory performance. In addition, in order to confirm the effects of BPA on spatial memory performance, we examined whether intrahippocampal injection of BPA affects spatial memory consolidation. In the MAZE test, although oral BPA administration at 10?mg/kg significantly altered the number of entries into the incorrect area compared to those of vehicle-treated rats, male rats given BPA through either oral administration or intrahippocampal injection failed to show significant differences in latencies to reach the reward. Also, oral BPA administration did not affect fear-motivated memory performance in the step-through passive avoidance test. Oral BPA administration at 0.05?mg/kg, the lowest dose used in this study, was correlated with a decrease in locomotor activity in the open-field test, whereas oral administration at 10?mg/kg, the highest dose used in this study, was correlated with a light anxiolytic effect in the elevated plus-maze test. The present study suggests that BPA in adulthood has little effect on spatial memory performance in male rats.