The epidemiology of hospitalized influenza in children, a two year population-based study in the People's Republic of China

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• 作者：Wei Ji (1)
  Tao Zhang (2)
  Xuelan Zhang (1)
  Lufang Jiang (2)
  Yunfang Ding (1)
  Chuangli Hao (1)
  Liwen Ju (2)
  Yuqing Wang (1)
  Qingwu Jiang (2)
  Mark Steinhoff (3)
  Steven Black (3)
  Genming Zhao (2)
  
• 刊名：BMC Health Services Research
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：10
• 期：1
• 全文大小：481KB
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• 作者单位：Wei Ji (1)
  Tao Zhang (2)
  Xuelan Zhang (1)
  Lufang Jiang (2)
  Yunfang Ding (1)
  Chuangli Hao (1)
  Liwen Ju (2)
  Yuqing Wang (1)
  Qingwu Jiang (2)
  Mark Steinhoff (3)
  Steven Black (3)
  Genming Zhao (2)
  
  1. Suzhou Children's Hospital, Suzhou University, Jiangsu Province, PR, China
  2. Department of Epidemiology, School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, PR, China
  3. Center for Global Health, Cincinnati Children's Hospital, Cincinnati, Ohio, USA
  

文摘

Background The epidemiology and disease burden of annual influenza in children in mainland People's Republic of China have not been reported in detail. To understand the incidence and epidemiology of laboratory-proven influenza hospitalization in children in China, a review of available laboratory and hospital admission data was undertaken. Methods We conducted a retrospective population-based study in Suzhou and the surrounding area of Jiangsu province, China for hospitalized cases of respiratory illness at Suzhou Children's Hospital. Cases of pneumonia or respiratory illness were identified from hospital computer data bases. Routine virological testing by fluorescent monoclonal antibody assay of all hospitalized children identified influenza and other viruses. We calculated incidence rates using census population denominators. Results Of 7,789 specimens obtained during 2007 and 2008, 85 were positive for influenza A and 25 for influenza B. There were 282 specimens with parainfluenza virus and 1392 with RSV. Influenza occurred throughout the year, with peaks in the winter, and in August/September. Overall estimated annual incidence of laboratory-proven influenza hospitalization was 23-27/100,000 children 0-4 years old, and 60/100,000 in infants 0-6 months, with an average hospitalization of 9 days. Conclusions Influenza disease in young children in this part of China is a relatively common cause of hospitalization, and occurs throughout the year. The use of influenza vaccine in Chinese children has the potential to reduce the effect of influenza in the children, as well as in their communities. Studies are needed to further assess the burden of influenza, and to develop and refine effective strategies of immunization of young children in China.