miR-203a regulates proliferation, migration, and apoptosis by targeting glycogen synthase kinase-3β in human renal cell carcinoma
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- 作者：Guanghui Hu (1)
Peng Lai (1)
Min Liu (1)
Liang Xu (1)
Zhuifeng Guo (1)
Huan Liu (1)
Wei Li (1)
Gangchun Wang (1)
Xudong Yao (1)
Junhua Zheng (1)
Yunfei Xu (1) - 关键词：miR ; 203a ; Renal cell cancer ; Proliferation ; Migration ; Apoptosis ; Glycogen synthase kinase ; 3β ; Prognosis
- 刊名：Tumor Biology
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：35
- 期：11
- 页码：11443-11453
- 全文大小：2,497 KB
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Peng Lai (1)
Min Liu (1)
Liang Xu (1)
Zhuifeng Guo (1)
Huan Liu (1)
Wei Li (1)
Gangchun Wang (1)
Xudong Yao (1)
Junhua Zheng (1)
Yunfei Xu (1)
1. Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, 301 Yanchang Road, Shanghai, 200072, China- ISSN：1423-0380
- 作者单位：Guanghui Hu (1)
文摘
MicroRNAs play a crucial role in cancer progression and metastasis. miR-203a has been identified as a tumor suppressor in various cancers. However, its functions in renal cell carcinoma have not been illustrated. In this study, we detected the miR-203a expression in renal cell carcinoma and evaluated its association with clinical features. Overexpression of miR-203a was found in renal cell carcinoma tissues and renal cell carcinoma cells. High miR-203a expression is correlated with tumor stage and short overall survival time. Bioinformatics and luciferase assay confirmed that glycogen synthase kinase-3β was a target gene of miR-203a. Silencing of miR-203a could inhibit cell proliferation and migration, arrest them in G1 phase, and promote apoptosis in vitro. miR-203a promotes the progression of renal cell carcinoma and predicts a poor prognosis.