Baicalein protects against the development of angiotensin II-induced abdominal aortic aneurysms by blocking JNK and p38 MAPK signaling
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- 作者：Fang Wang ; Houzao Chen ; Yunfei Yan ; Yue Liu ; Shuyang Zhang…
- 关键词：baicalein ; abdominal aortic aneurysm ; oxidative stress ; vascular inflammation ; extracellular matrix degradation ; AT1R ; MAPKs
- 刊名：Science China Life Sciences
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：59
- 期：9
- 页码：940-949
- 全文大小：1,516 KB
- 刊物主题：Life Sciences, general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1869-1889
- 卷排序：59
文摘
An abdominal aortic aneurysm (AAA) is a permanent, localized dilatation of the abdominal aorta. In western countries, the morbidity of AAA is approximately 8%. Currently, pharmacotherapies for AAA are limited. Here, we demonstrate that baicalein (BAI), the main component of the Chinese traditional drug “Huang Qin”, attenuates the incidence and severity of AAA in Apoe-/- mice infused with angiotensin II (AngII). Mechanically, BAI treatment decreases AngII-induced reactive oxygen species (ROS) production in the aortic wall. Moreover, BAI inhibits inflammatory cell accumulation in the aortas of mice infused with AngII. It also inhibits AngII-induced activation of matrix metalloproteinase 2 (MMP-2) and MMP-9 to maintain elastin content in vivo. In addition, it blocks AngII cascade by downregulating angiotensin type 1 receptor (AT1R) and inhibiting mitogen-activated protein kinases (MAPKs). Taken together, our findings show that BAI is an effective agent for AAA prevention.