Mass spectrometry based phospholipidomics of mammalian thymus and leukemia patients: implication for function of iNKT cells
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- 作者：Xiukun Xu (1)
Yunhui Yu (1)
Zheng Wang (1)
Tingting Zhu (1)
Yanping Wang (1)
Jian Zhu (1)
Zijun Chen (2)
Yun He (1)
Linling Ju (1)
Yunsen Li (1) - 关键词：Phospholipids ; Natural killer T cells ; Lipidomics ; Peroxisome ; derived lipids ; Function
- 刊名：Analytical and Bioanalytical Chemistry
- 出版年：2013
- 出版时间：June 2013
- 年：2013
- 卷：405
- 期：15
- 页码：5267-5278
- 全文大小：642KB
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Yunhui Yu (1)
Zheng Wang (1)
Tingting Zhu (1)
Yanping Wang (1)
Jian Zhu (1)
Zijun Chen (2)
Yun He (1)
Linling Ju (1)
Yunsen Li (1)
1. Laboratory of Cellular and Molecular Tumor Immunology, Institutes of Biology and Medical Sciences, Jiangsu Laboratory of Infection Immunity, Soochow University, 199 Ren-Ai Road, Suzhou, 215123, China
2. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 530 Lingling Road, Shanghai, China - ISSN：1618-2650
文摘
In previous studies phospholipids have been proved to be involved in biochemical, physiological, and pathological processes. As a special class of phospholipids, peroxisome-derived lipids (PDLs) have been proved to be potential ligands of invariant natural killer T (iNKT) cells in recent studies. Here, on the basis of phospholipidomics, we focused on the relative quantity of PDLs extracted from mammalian thymus or bone marrow using electrospray ionization mass spectrometry (MS). In phospholipid analysis, we identified 12 classes of phospholipids and accounted for their relative quantities by comparing their relative abundances in the MS1 map. Our results show that PDLs are present in mammalian thymus as well as mouse spleen and liver. Interestingly, the relative quantity of PDLs extracted from human acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) bone marrows is higher than that extracted from bone marrow of healthy donors. Our results may help to explain the close correlation between PDLs and iNKT cell function in thymus, spleen, liver, and especially in leukemia patients. We think that our phospholipidomics work may reveal a function of iNKT cells.