Simultaneous determination of 18 d-amino acids in rat plasma by an ultrahigh-performance liquid chromatography-tandem mass spectrometry method: application to explore the potential relationship be

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• 作者：Yuping Xing ; Xiaoyan Li ; Xingjie Guo ; Yan Cui
• 关键词：d ; Amino acids ; Pre ; column derivatization ; UPLC ; MS/MS ; Alzheimer’s disease ; Biomarkers
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：408
• 期：1
• 页码：141-150
• 全文大小：371 KB
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• 作者单位：Yuping Xing (1)
  Xiaoyan Li (1)
  Xingjie Guo (1)
  Yan Cui (1)
  
  1. School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning, 110016, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

d-Amino acids are increasingly being recognized as important signaling molecules, and abnormal levels of d-amino acids have been implicated in the pathogenesis of Alzheimer’s disease. To evaluate the potential relationship between Alzheimer’s disease and d-amino acids, a simple, sensitive, and reliable UPLC-MS/MS method with pre-column derivatization was developed and validated for simultaneous determination of 18 d-amino acids in rat plasma. The analytes were extracted from plasma samples by a protein precipitation procedure, and then derivatized with (S)-N-(4-nitrophenoxycarbonyl) phenylalanine methoxyethyl ester [(S)-NIFE]. Chromatographic separation was achieved using an ACQUITY UPLC BEH C₁₈ column (2.1 mm × 50 mm, 1.7 μm) with a mobile phase composed of acetonitrile containing 8 mM ammonium hydrogen carbonate at a flow rate of 0.6 mL min−1. The analytes were detected by electrospray ionization in positive ion multiple reaction monitoring modes. Under the optimum experimental conditions, all the linear regressions were acquired with r > 0.9932. The limits of quantitation of all derivatized d-amino acids were within 0.05–40.0 ng mL−1 in rat plasma. The intra- and inter-day precisions, expressed as percentage relative standard deviations (%RSD), were within the range of 12.3 and 10.1 %, respectively. The recoveries for all the analytes were observed over the range of 82.8–100.5 % with RSD values less than 12.5 %. Finally, the proposed method was successfully applied to simultaneous determination of the 18 d-amino acids in plasma from Alzheimer’s disease rats and age-matched normal controls. Results showed that the concentrations of d-serine, d-aspartate, d-alanine, d-leucine, and d-proline in Alzheimer’s disease rat plasma were significantly decreased compared with those in normal controls, while d-phenylalanine levels increased. It was revealed that some of these d-amino acids would be potential diagnostic biomarkers for Alzheimer’s disease.