Genetic control and regulatory mechanisms of succinoglycan and curdlan biosynthesis in genus Agrobacterium

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• 作者：Dan Wu ; Ang Li ; Fang Ma ; Jixian Yang ; Yutong Xie
• 刊名：Applied Microbiology and Biotechnology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：100
• 期：14
• 页码：6183-6192
• 全文大小：788 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Microbiology
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0614
• 卷排序：100

文摘

Agrobacterium is a genus of gram-negative bacteria that can produce several typical exopolysaccharides with commercial uses in the food and pharmaceutical fields. In particular, succinoglycan and curdlan, due to their good quality in high yield, have been employed on an industrial scale comparatively early. Exopolysaccharide biosynthesis is a multiple-step process controlled by different functional genes, and various environmental factors cause changes in exopolysaccharide biosynthesis through regulatory mechanisms. In this mini-review, we focus on the genetic control and regulatory mechanisms of succinoglycan and curdlan produced by Agrobacterium. Some key functional genes and regulatory mechanisms for exopolysaccharide biosynthesis are described, possessing a high potential for application in metabolic engineering to modify exopolysaccharide production and physicochemical properties. This review may contribute to the understanding of exopolysaccharide biosynthesis and exopolysaccharide modification by metabolic engineering methods in Agrobacterium.KeywordsExopolysaccharideAgrobacteriumGenetic controlRegulatory mechanisms