Current Trends in 3D Printing, Bioprosthetics, and Tissue Engineering in Plastic and Reconstructive Surgery

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• 作者：Cesar Colasante ; Zachary Sanford ; Evan Garfein ; Oren Tepper
• 关键词：3D printing ; Tissue engineering ; Bioprosthetics ; Biomaterials ; Plastic surgery ; Reconstructive surgery
• 刊名：Current Surgery Reports
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：4
• 期：3
• 全文大小：1,257 KB
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  92.• Michael S, Sorg H, Peck CT, et al. Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice. PLoS One 2013;8:e57741. The authors utilized a laser-assisted bioprinting (LaBP) technique to create a fully cellularized skin substitute allowing printing different cell types in a 3D spatial pattern. It was then implanted into full thickness wound of mice. Their results showed tissue formation in vivo on the construct. This technique overcomes a very important hurdle in the journey for 3D printing complex tissues.
  93.• Bertassoni LE, Cecconi M, Manoharan V, et al. Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip 2014;14:2202–11. Blood supply to newly engineered tissues is barrier in transplantation. In this study the authors created vascular networks in hydrogels and demonstrated the functionality of the fabricated vascular networks in improving mass transport, cellular viability and differentiation within the cell-laden tissue constructs. Also formation of endothelial monolayers within the fabricated channels was confirmed. This is a breakthrough in tissue engineering of complex tissues.
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• 作者单位：Cesar Colasante (1)
  Zachary Sanford (2)
  Evan Garfein (3)
  Oren Tepper (3)
  
  1. Division of Plastic and Reconstructive Surgery, Department of Surgery, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
  2. Joan C. Edwards School of Medicine (JCESOM), Marshall University, Huntington, WV, 25701, USA
  3. Division of Plastic and Reconstructive Surgery, Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
  
• 刊物主题：Surgery;
• 出版者：Springer US
• ISSN：2167-4817

文摘

3D printing represents a developing technology whose applications in plastic and reconstructive science are only in its dawn, creating devices of limitless customization presenting the possibility for uniquely tailored implantable devices for the individual patient. The advent of tissue engineering presents exciting new possibilities for conventional 3D printing in that novel approaches to reconstruction can be attempted with bioactive molecules and tissues for advanced wound healing, thereby resulting in a dramatic reduction in implantable device morbidity with improved esthetic results. The marriage of these two technologies has resulted in the creation of bioprosthetics, a field in which bioactive molecules are structured into implantable prosthetic devices through 3D printing of cells harvested or engineered in the laboratory. The historical context of conventional 3D printing modalities as well as tissue engineering is presented for discussion in the greater context of the creation of modern bioprosthetics. An outline of common materials, methods, and their utility is also introduced to serve as a framework to better understand the continuing advancements in implantable devices with examples of continuing discoveries discussed where appropriate. Keywords 3D printing Tissue engineering Bioprosthetics Biomaterials Plastic surgery Reconstructive surgery