Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific hybrid voles

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• 作者：K. E. Orischenko ; E. A. Elisaphenko and S. M. Zakian
• 刊名：Russian Journal of Genetics
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：46
• 期：10
• 页码：1233-1235
• 全文大小：526.1 KB

文摘

Interaction of transcription factor CTCF with the minimal promoter of Xist gene was investigated in intraspecific hybrids of common voles. CTCF was shown to bind with the minimal promoter region in vivo. However, the EMSA experiments resulted in the absence of interaction between the CTCF factor and its potential binding site. Probably, G(-43)A substitution influences binding efficacy of another transcription factor such as activator protein 2, AP2.