Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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- 作者：Cecilie Kyrø ; Raul Zamora-Ros ; Augustin Scalbert…
- 关键词：Breast cancer ; Survivorship ; Polyphenols ; Phytoestrogens ; Lignans
- 刊名：Breast Cancer Research and Treatment
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：154
- 期：2
- 页码：389-401
- 全文大小：545 KB
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41.Shike M, Doane AS, Russo L, Cabal R, Reis-Filho JS, Gerald W, Cody H, Khanin R, Bromberg J, Norton L (2014) The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study. J Natl Cancer Inst 106(9). doi:10.1093/jnci/dju189 - 作者单位：Cecilie Kyrø (1) (2)
Raul Zamora-Ros (2)
Augustin Scalbert (2)
Anne Tjønneland (1)
Laure Dossus (3) (4)
Christoffer Johansen (1) (5)
Pernille Envold Bidstrup (1)
Elisabete Weiderpass (6) (7) (8) (9)
Jane Christensen (1)
Heather Ward (10)
Dagfinn Aune (10)
Elio Riboli (10)
Mathilde His (11) (3) (4)
Françoise Clavel-Chapelon (11) (3) (4)
Laura Baglietto (11) (12) (13) (3) (4)
Verena Katzke (14)
Tilman Kühn (14)
Heiner Boeing (15)
Anna Floegel (15)
Kim Overvad (16)
Cristina Lasheras (17)
Noémie Travier (18)
Maria-José Sánchez (19) (20)
Pilar Amiano (20) (21)
Maria-Dolores Chirlaque (20) (22) (23)
Eva Ardanaz (20) (24) (25)
Kay-Tee Khaw (26)
Nick Wareham (27)
Aurora Perez-Cornago (28)
Antonia Trichopoulou (29) (30)
Pagona Lagiou (29) (30)
Effie Vasilopoulou (29) (30)
Giovanna Masala (31)
Sara Grioni (32)
Franco Berrino (32)
Rosario Tumino (33)
Carlotta Sacerdote (34)
Amalia Mattiello (35)
H. B(as). Bueno-de-Mesquita (10) (36) (37) (38)
Petra H. Peeters (10) (39)
Carla van Gils (39)
Signe Borgquist (40)
Salma Butt (41)
Anne Zeleniuch-Jacquotte (42)
Malin Sund (43)
Anette Hjartåker (44)
Guri Skeie (6)
Anja Olsen (1)
Isabelle Romieu (2)
1. Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark
2. International Agency for Research on Cancer (WHO–IARC), Lyon, France
3. Inserm, CESP Centre for Research in Epidemiology and Population Health, Villejuif, France
4. Université Paris-Sud, Villejuif, France
5. 5073, Oncology Clinic, Finsen Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
6. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
7. Department of Research, Cancer Registry of Norway, Institute of Population Based Cancer Research, Oslo, Norway
8. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
9. Genetic Epidemiology Group, Folkhälsan Research Center, Samfundet Folkhälsan, Helsinki, Finland
10. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
11. Gustave Roussy, Villejuif, France
12. Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, VIC, Australia
13. Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia
14. Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
15. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
16. Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
17. Department of Functional Biology, Faculty of Medicine, University of Oviedo, Asturias, Spain
18. Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
19. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
20. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
21. Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastián, Spain
22. Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
23. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
24. Navarra Public Health Institute, Pamplona, Spain
25. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
26. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
27. MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
28. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
29. Hellenic Health Foundation, Athens, Greece
30. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
31. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
32. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
33. Cancer Registry and Histopathology Unit, “Civile–M.P. Arezzo” Hospital, ASP, Ragusa, Italy
34. Cancer Epidemiology Unit, San Giovanni Battista Hospital, CPO Piemonte and University of Turin, Turin, Italy
35. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
36. Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
37. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands
38. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
39. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
40. Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden
41. Department of Surgery, Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden
42. Department of Population Health, NYU School of Medicine, New York, NY, USA
43. Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
44. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology - 出版者：Springer Netherlands
- ISSN：1573-7217
文摘
The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific mortality using Cox proportional hazard models with time since diagnosis as underlying time and strata for age and country. Among postmenopausal women, an intake of lignans in the highest versus lowest quartile was related to a 28 % lower risk of dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72, 95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive association between lignan intake and all-cause mortality was found (adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03; 2.57). We found no association for other polyphenol classes. Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. This suggests that the role of phytoestrogens in breast cancer survival is complex and may be dependent of menopausal status.