Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

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• 作者：Raul Zamora-Ros (1)
  Pietro Ferrari (2)
  Carlos A. González (1)
  Anne Tj?nneland (3)
  Anja Olsen (3)
  Lea Bredsdorff (4)
  Kim Overvad (5)
  Marina Touillaud (6) (7) (8)
  Florence Perquier (6) (7) (8)
  Guy Fagherazzi (6) (7) (8)
  Annekatrin Lukanova (9)
  Kaja Tikk (9)
  Krasimira Aleksandrova (10)
  Heiner Boeing (10)
  Antonia Trichopoulou (11) (12)
  Dimitrios Trichopoulos (11) (13) (14)
  Vardis Dilis (11)
  Giovanna Masala (15)
  Sabina Sieri (16)
  Amalia Mattiello (17)
  Rosario Tumino (18)
  Fulvio Ricceri (41)
  H. Bas Bueno-de-Mesquita (20) (21)
  Petra H. M. Peeters (22) (23)
  Elisabete Weiderpass (24) (25) (26) (27)
  Guri Skeie (24)
  Dagrun Engeset (24)
  Virginia Menéndez (28)
  Noémie Travier (1)
  Esther Molina-Montes (29) (30)
  Pilar Amiano (30) (31)
  Maria-Dolores Chirlaque (30) (32)
  Aurelio Barricarte (30) (33)
  Peter Wallstr?m (34)
  Emily Sonestedt (35)
  Malin Sund (36)
  Rikard Landberg (37)
  Kay-Thee Khaw (38)
  Nicholas J. Wareham (39)
  Ruth C. Travis (40)
  Augustin Scalbert (2)
  Heather A. Ward (23)
  Elio Riboli (19)
  Isabelle Romieu (2)
  
• 关键词：Flavonoids ; Lignans ; Breast cancer ; Hormone receptors ; EPIC
• 刊名：Breast Cancer Research and Treatment
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：139
• 期：1
• 页码：163-176
• 全文大小：229KB
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• 作者单位：Raul Zamora-Ros (1)
  Pietro Ferrari (2)
  Carlos A. González (1)
  Anne Tj?nneland (3)
  Anja Olsen (3)
  Lea Bredsdorff (4)
  Kim Overvad (5)
  Marina Touillaud (6) (7) (8)
  Florence Perquier (6) (7) (8)
  Guy Fagherazzi (6) (7) (8)
  Annekatrin Lukanova (9)
  Kaja Tikk (9)
  Krasimira Aleksandrova (10)
  Heiner Boeing (10)
  Antonia Trichopoulou (11) (12)
  Dimitrios Trichopoulos (11) (13) (14)
  Vardis Dilis (11)
  Giovanna Masala (15)
  Sabina Sieri (16)
  Amalia Mattiello (17)
  Rosario Tumino (18)
  Fulvio Ricceri (41)
  H. Bas Bueno-de-Mesquita (20) (21)
  Petra H. M. Peeters (22) (23)
  Elisabete Weiderpass (24) (25) (26) (27)
  Guri Skeie (24)
  Dagrun Engeset (24)
  Virginia Menéndez (28)
  Noémie Travier (1)
  Esther Molina-Montes (29) (30)
  Pilar Amiano (30) (31)
  Maria-Dolores Chirlaque (30) (32)
  Aurelio Barricarte (30) (33)
  Peter Wallstr?m (34)
  Emily Sonestedt (35)
  Malin Sund (36)
  Rikard Landberg (37)
  Kay-Thee Khaw (38)
  Nicholas J. Wareham (39)
  Ruth C. Travis (40)
  Augustin Scalbert (2)
  Heather A. Ward (23)
  Elio Riboli (19)
  Isabelle Romieu (2)
  
  1. Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Avda Gran Via 199-203, L’Hospitalet de Llobregat, 08907, Barcelona, Spain
  2. Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France
  3. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
  4. Technical University of Denmark, National Food Institute, Soeborg, Denmark
  5. Section for Epidemiology, Department of Public Health, Aarhus University, ?rhus, Denmark
  6. Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health Team, Inserm, 94805, Villejuif, France
  7. Paris South University, UMRS 1018, Villejuif, France
  8. Institut Gustave-Roussy (IGR), 94805, Villejuif, France
  9. Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
  10. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
  11. Hellenic Health Foundation, Athens, Greece
  12. Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, WHO Collaborating Center for Food and Nutrition Policies, Athens, Greece
  13. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
  14. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece
  15. Molecular and Nutritional Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Florence, Italy
  16. Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  17. Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
  18. Cancer Registry and Histopathology Unit, “Civile M.P. Arezzo-Hospital, Ragusa, Italy
  41. Human Genetics Foundation (HUGEF), Turin, Italy
  20. Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
  21. Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands
  22. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
  23. Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College, London, UK
  24. Department of Community Medicine, University of Troms?, Troms?, Norway
  25. Cancer Registry of Norway, Oslo, Norway
  26. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  27. Samfundet Folkh?lsan, Helsinki, Finland
  28. Public Health Directorate, Asturias, Spain
  29. Andalusian School of Public Health, Granada, Spain
  30. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  31. Public Health Department of Gipuzkoa, Basque Government, San Sebastián, Spain
  32. Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain
  33. Public Health Institute of Navarra, Pamplona, Spain
  34. Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malm?, Sweden
  35. Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malm?, Sweden
  36. Departments of Surgical and Perioperative Sciences, Surgery and Public Health and Clinical Medicine, Nutrition Research, Ume? University, Ume?, Sweden
  37. Department of Food Science, BioCenter, Swedish University of Agriculture Science, Uppsala, Sweden
  38. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  39. MRC Epidemiology Unit, Cambridge, UK
  40. Cancer Epidemiology Unit, University of Oxford, Oxford, UK
  19. School of Public Health, Imperial College, London, UK
  
• ISSN：1573-7217

文摘

Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70?years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5–Q1) 0.97, 95?% confidence interval (CI): 0.90-.04; P trend?=?0.591], isoflavones (HRQ5–Q1 1.00, 95?% CI: 0.91-.10; P trend?=?0.734), or total lignans (HRQ5–Q1 1.02, 95?% CI: 0.93-.11; P trend?=?0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.