Chemical constituents with NO production inhibitory and cytotoxic activities from Litsea cubeba
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- 作者：Qiang Guo (1) (2)
Kewu Zeng (3)
Xiaoli Gao (1)
Zhixiang Zhu (1)
Shuiying Zhang (1) (2)
Xingyun Chai (1)
Pengfei Tu (1) - 关键词：Litsea cubeba ; Lauraceae ; Anti ; inflammatory activity ; Cytotoxicity
- 刊名：Journal of Natural Medicines
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：69
- 期：1
- 页码：94-99
- 全文大小：333 KB
- 参考文献：1. Zhang SY, Guo Q, Gao XL, Guo ZQ, Zhao YF, Chai XY, Tu PF (2014) A phytochemical and pharmacological advance on medicinal plant / Litsea cubeba (Lauraceae). Chin J Chin Mater Med 39:769-76
2. Lin B, Zhang H, Zhao XX, Rahman K, Wang Y, Ma XQ, Zheng CJ, Zhang QY, Han T, Qin LP (2013) Inhibitory effects of the root extract of / Litsea cubeba (Lour.) per. on adjuvant arthritis in rats. J Ethnopharmacol 147:327-34 CrossRef
3. Zhang SY, Guo Q, Cao Y, Zhang YF, Gao XL, Tu PF, Chai XY (2014) Alkaloids from the roots and stems of / Litsea cubeba. Chin J Chin Mater Med 39:51-5
4. Chen CY, Chang FR, Yen HF, Wu YC (1998) Amides from stems of / Annona cherimola. Phytochemistry 49:1443-447 CrossRef
5. Jiang M, Lin S, Guo QL, Jiang ZB, Wang SJ, Yang YC, Lin PC (2013) Chemical constituents from / Litsea greenmaniana. Chin J Chin Mater Med 38:1004-007
6. Fuchino H, Satoh T, Tanaka N (1995) Chemical evaluation of / Betula species in Japan. I. Constituents of / Betula ermanii. Chem Pharm Bull 43:1937-942 CrossRef
7. Xie LH, Akao T, Hamasaki K, Deyama T, Hattori M (2003) Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of / Enterococcus faecalis strain PDG-1 responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol. Chem Pharm Bull 51:508-15 CrossRef
8. Kuroda M, Sakurai K, Mimaki Y (2011) Chemical constituents of the stems and twigs of / Lindera umbellata. J Nat Med 65:198-01 CrossRef
9. Chen TH, Huang YH, Lin JJ, Liau BC, Wang SY, Wu YC, Jong TT (2010) Cytotoxic lignan esters from / Cinnamomum osmophloeum. Planta Med 76:613-19 CrossRef
10. Lee TH, Kuo YC, Wang GJ, Kuo YH, Chang CI, Lu CK, Lee CK (2002) Five new phenolics from the roots of / Ficus beecheyana. J Nat Prod 65:1497-500 CrossRef
11. Jang DS, Park EJ, Kang YH, Vigo JS, Graham JG, Cabieses F, Fong HHS, Pezzuto JM, Kinghorn AD (2004) Phenolic compounds obtained from stems of / Couepia ulei with the potential to induce quinone reductase. Arch Pharm Res 27:169-72 CrossRef
12. Youssef D, Frahm AW (1995) Constituents of the Egyptian / Centaurea scoparia; III. Phenolic constituents of the aerial parts. Planta Med 61:570-73 CrossRef
13. Ma GX, Wu HF, Yuan JQ, Wu LZ, Zheng QX, Sun ZC, Fan XR, Wei H, Yang JS, Xu XD (2013) Phenylpropanoid constituents from the seeds of / Lithocarpus pachylepis. Phytochem Lett 6:152-55 CrossRef
14. Wang M, Liang JY, Liu XT, Qiu W (2006) Chemical constituents from / Serissa serissoides. Chin J Nat Med 4:198-01
15. Chen ZJ, Bi HP, Fang CJ, Bao CY (2013) Chemical constituents from the branch of / Litsea cubeba (Lour.) Pers. Chem Ind Forest Prod 33:133-36
16. Tanaka H, Yatsuhashi S, Yasuda T, Sato M, Sakai E, Xiao C, Murata H, Murata J (2009) A new amide from the leaves and twigs of / Litsea auriculata. J Nat Med 63:331-34 CrossRef
17. Williamson EM (2001) Synergy and other interactions in phytomedicines. Phytomedicine 8:401-09 CrossRef
18. Wagner H, Ulrich-Merzenich G (2009) Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine 16:97-10 CrossRef
19. Chen D, Xu Z, Chai X, Zeng K, Jia Y, Bi D, Ma Z, Tu P (2012) Nine 2-(2-phenylethyl)chromone derivative from the resinous wood of / Aquilaria sinensis and their inhibition of LPS-induced NO production in RAW 264.7 cells. Eur J Org Chem 27:5389-397- 作者单位：Qiang Guo (1) (2)
Kewu Zeng (3)
Xiaoli Gao (1)
Zhixiang Zhu (1)
Shuiying Zhang (1) (2)
Xingyun Chai (1)
Pengfei Tu (1)
1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, People’s Republic of China
3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, People’s Republic of China- ISSN：1861-0293
- 作者单位：Qiang Guo (1) (2)
文摘
A bioassay-guided fractionation of the roots and stems of Litsea cubeba led to the isolation of 14 constituents, including three new compounds, cubebanone (1), N-cis-3,4-methylenedioxycinnamoyl-3-methoxytyramine (2), and 9,9-O-di-(E)-feruloyl-(+)-secoisolariciresinol (3), together with 11 known ones (4-strong class="a-plus-plus">14). Compounds 1, 4, and 8-strong class="a-plus-plus">11 showed obvious in vitro anti-inflammatory activities against NO production in LPS-induced murine microglial (BV-2) cell line and RAW 264.7 macrophages. A cytotoxic evaluation showed that 2, 3, and 5-strong class="a-plus-plus">8 exhibited considerable inhibition against the growth of hepatocyte carcinoma (HepG2) cell line. These findings are evidence, to some extent, for the traditional medicinal application of L. cubeba, especially as folk medicine in the treatment of inflammation-related diseases.