Association between high-sensitivity C-reactive protein and hyperuricemia

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• 作者：Tuo Yang ; Xiang Ding ; Yi-lun Wang ; Chao Zeng ; Jie Wei ; Hui Li…
• 关键词：High ; sensitivity C ; reactive protein ; Hyperuricemia ; Cross ; sectional study
• 刊名：Rheumatology International
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：36
• 期：4
• 页码：561-566
• 全文大小：407 KB
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• 作者单位：Tuo Yang (1)
  Xiang Ding (1)
  Yi-lun Wang (1)
  Chao Zeng (1)
  Jie Wei (2) (3)
  Hui Li (1)
  Yi-lin Xiong (1)
  Shu-guang Gao (1)
  Yu-sheng Li (1)
  Guang-hua Lei (1)
  
  1. Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, 410008, Hunan Province, China
  2. Health Management Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China
  3. Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, 410008, Hunan Province, China
  
• 刊物主题：Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1437-160X

文摘

The aim of the study was to examine the cross-sectional association between high-sensitivity C-reactive protein (hsCRP) and hyperuricemia (HU). The hsCRP was measured by latex turbidity method. Uric acid was detected on Beckman Coulter AU 5800. HU was defined as uric acid ≥416 μmol/L for the male population and ≥360 μmol/L for the female population. A multivariable logistic analysis model was applied to test the association after adjusting for a number of potential confounding factors. A total of 1935 subjects were included in this study. According to the multivariable regression model, the relative odds of the prevalence of HU were increased by 0.56 times in the third quintile (OR 1.56, 95 % CI 1.03–2.38, P = 0.04), 0.55 times in the fourth quintile (OR 1.55, 95 % CI 1.01–2.36, P = 0.04) and 0.96 times in the fifth quintile (OR 1.96, 95 % CI 1.29–2.98, P < 0.01) of hsCRP comparing with the lowest quintile, and P for trend was smaller than 0.01. In the male population, a positive association existed in the highest quintile of hsCRP (OR 1.66, 95 % CI 1.04–2.66, P = 0.04), and P for trend was 0.07. In the female population, the multivariable-adjusted ORs (95 % CI) of HU in the fourth and fifth quintile of hsCRP were 3.02 (95 % CI 1.09–8.35, P = 0.03) and 3.66 (95 % CI 1.36–9.89, P = 0.01), respectively, and P for trend was smaller than 0.01. The findings of this cross-sectional study suggest that the hsCRP level is positively associated with the prevalence of HU.