The associations of serum uric acid level and hyperuricemia with knee osteoarthritis

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• 作者：Xiang Ding ; Chao Zeng ; Jie Wei ; Hui Li ; Tuo Yang ; Yi Zhang…
• 关键词：Osteoarthritis ; Knee ; Uric acid ; Hyperuricemia
• 刊名：Rheumatology International
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：36
• 期：4
• 页码：567-573
• 全文大小：421 KB
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• 作者单位：Xiang Ding (1)
  Chao Zeng (1)
  Jie Wei (2)
  Hui Li (1)
  Tuo Yang (1)
  Yi Zhang (1)
  Yi-lin Xiong (1)
  Shu-guang Gao (1)
  Yu-sheng Li (1)
  Guang-hua Lei (1)
  
  1. Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, 410008, Hunan, China
  2. Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, 410008, Hunan, China
  
• 刊物主题：Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1437-160X

文摘

To examine the cross-sectional associations of the serum uric acid level and hyperuricemia (HU) with the radiographic features of osteoarthritis (OA), including osteophytes (OST) and joint space narrowing (JSN), a total of 4685 subjects were included in this study. Blood samples were drawn from all subjects. Serum uric acid and some other indexes were detected. OST and JSN were assessed for each subject according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the target associations after adjusting a number of potential confounding factors. The prevalence of OST was increased in the highest tertile of uric acid compared to the lowest in female subjects (OR 1.46, 95 % CI 1.07–1.99, P for trend = 0.02). Meanwhile, a positive association between OST and HU was observed in female subjects (OR 1.43, 95 % CI 1.01–2.03, P = 0.05). However, serum uric acid and HU were not significantly associated with JSN in male subjects. The findings of this study indicated that the serum uric acid concentration and prevalence of HU are positively associated with OST of the knee in the female population. Level of evidence Cross-sectional study, Level III.