Syntheses, Crystal Structures and Biological Activity of the 1D Chain Benzyltin Complexes Based on 2-Oxo-Propionic Acid Benzoyl Hydrazone

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• 作者：Yu-Xing Tan ; Zhi-Jian Zhang ; Yong-Lan Feng…
• 关键词：Organotin ; Hydrazone ; Synthesis ; Crystal structure ; Biological activity
• 刊名：Journal of Inorganic and Organometallic Polymers and Materials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：342-352
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Inorganic Chemistry; Organic Chemistry; Polymer Sciences;
• 出版者：Springer US
• ISSN：1574-1451
• 卷排序：27

文摘

Two new 1D Chain benzyltin complexes {[C₆H₄(O)C=N–N=C(Me)COO](CH₃OH)(C₆H₅CH₂)₂Sn}_n (1), {[C₆H₄(O)C–NH–N=C(Me)COO](C₆H₅CH₂)₃Sn}_n (2) were synthesized by the reactions of 2-oxo-propionic acid benzoyl hydrazone with dibenzyltin dichloride or tribenzyltin chloride, respectively. The two complexes were characterized by FT-IR, 1H, 13C and 119Sn NMR spectra, elemental analysis, X-ray single crystal diffraction and TGA. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines (NCI-H460, HepG2, MCF7) and human cell line (HL7702). The 1 exhibited strong antitumor activity than 2, then it was expected after further chemical optimization of candidate compounds as anti-cancer drugs. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe, the interaction of 1 and 2 with calf thymus DNA were intercalation and electrostatic attraction.