Activation of Cold-Sensitive Channels TRPM8 and TRPA1 Inhibits the Proliferative Airway Smooth Muscle Cell Phenotype

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• 作者：Lin Zhang ; Xiaofei An ; Qiuyu Wang ; Ming He
• 刊名：Lung
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：194
• 期：4
• 页码：595-603
• 全文大小：1,932 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pneumology and Respiratory System
  
• 出版者：Springer New York
• ISSN：1432-1750
• 卷排序：194

文摘

PurposeAirway smooth muscle cell (ASMC) phenotypic modulation is one of the key factors contributing to asthma. Temperature changes may induce asthma, and these changes are known to be related to the temperature-sensitive transient receptor potential channels (TS-TRPs). The present study was designed to investigate the cellular functions of cold-sensitive channels, TRPM8 and TRPA1, in the phenotypic modulation of ASMCs.