Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway
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- 作者：Jia-Xing Zhang ; Yi Xu ; Ying Gao ; Cui Chen ; Zhou-San Zheng ; Miao Yun…
- 关键词：miR ; 939 ; SLC34A2 ; Gastric cancer ; Chemoresistance ; Metastasis
- 刊名：Molecular Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：7039KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
- 卷排序：16
文摘
BackgroundThe development of chemoresistance and metastasis are the leading causes of death for gastric cancer (GC) patients, however, the molecular mechanisms involved remain unclear. Dysregulation of miRNAs is associated with a variety of disease, including GC. Recently, microarray profiling analysis revealed that miR-939 was dysregulated in human GC samples, but the role of miR-939 in GC has not been intensively investigated.