Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus
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- 作者：Ting Li (1)
Hong You (1)
Jie Zhang (1)
Xiaoye Mo (2)
Wenfang He (3)
Yang Chen (1)
Xiangqi Tang (1)
Zheng Jiang (1)
Ranran Tu (1)
Liuwang Zeng (1)
Wei Lu (1)
Zhiping Hu (1) - 关键词：GOLPH3 ; Golgi apparatus ; mTOR ; Stress ; Receptor ; PI4P
- 刊名：Molecular Neurobiology
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：49
- 期：3
- 页码：1449-1459
- 全文大小：
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Hong You (1)
Jie Zhang (1)
Xiaoye Mo (2)
Wenfang He (3)
Yang Chen (1)
Xiangqi Tang (1)
Zheng Jiang (1)
Ranran Tu (1)
Liuwang Zeng (1)
Wei Lu (1)
Zhiping Hu (1)
1. Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China
2. Department of Emergency, Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China
3. Department of Intensive Care Unit, The Second Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China - ISSN：1559-1182
文摘
Although the Golgi apparatus has been studied extensively for over 100?years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes. Increasing evidence suggests that the Golgi apparatus is a sensor and common downstream effector of stress signals in cell death pathways. It undergoes disassembly and fragmentation in several neurological disorders. Recent studies indicate that Golgi phosphoprotein 3 (GOLPH3 also known as GPP34/GMx33/MIDAS), a peripheral membrane protein of trans-Golgi network, represents an exciting new class of oncoproteins involved in cell signal transduction and is potentially mobilized by stress. In this review, we focus on the importance of GOLPH3 in vesicular trafficking, Golgi architecture maintenance, receptor sorting, protein glycosylation, and further discuss its potential in signal sensing in stress response.