Dynamic changes of HBV markers and HBV DNA load in infants born to HBsAg(+) mothers: can positivity of HBsAg or HBV DNA at birth be an indicator for HBV infection of infants?
详细信息 查看全文
- 作者：Tianyan Chen (9)
Jing Wang (9)
Yuling Feng (9)
Zhi Yan (9)
Tieying Zhang (9)
Minghui Liu (10)
Yun Bai (11)
Hongxia Song (9)
Hongli Liu (9)
Yuan Yang (9)
Jinfeng Liu (9)
Yingli He (9)
Yunru Chen (9)
Shulin Zhang (9)
Guihua Zhuang (9)
Xiaofeng Liang (12)
Zongyin Liu (13)
Xiaguang Xu (14)
Wei Chen (9)
Yong Liu (9)
Yingren Zhao (9) - 刊名：BMC Infectious Diseases
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：481 KB
- 参考文献：1. Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, / et al.: Epidemiological serosurvey of hepatitis B in China–declining HBV prevalence due to hepatitis B vaccination. / Vaccine 2009, 27:6550-557. CrossRef
2. Shao ZJ, Zhang L, Xu JQ, Xu DZ, Men K, Zhang JX, Cui HC, Yan YP: Mother-to-infant transmission of hepatitis B virus: a Chinese experience. / J Med Virol 2011, 83:791-95. CrossRef
3. Hou J, Liu Z, Gu F: Epidemiology and prevention of hepatitis B virus infection. / Int J Med Sci 2005, 2:50-7. CrossRef
4. Zhu Q, Yu G, Yu H, Lu Q, Gu X, Dong Z, Zhang X: A randomized control trial on interruption of HBV transmission in uterus. / Chin Med J (Engl) 2003, 116:685-87.
5. Shi Z, Yang Y, Ma L, Li X, Schreiber A: Lamivudine in late pregnancy to interrupt in utero transmission of hepatitis B virus: a systematic review and meta-analysis. / Obstet Gynecol 2010, 116:147-59. CrossRef
6. Sun KX, Li J, Zhu FC, Liu JX, Li RC, Zhai XJ, Li YP, Chang ZJ, Nie JJ, Zhuang H: A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women. / Vaccine 2012, 30:5335-340. CrossRef
7. Han GR, Cao MK, Zhao W, Jiang HX, Wang CM, Bai SF, Yue X, Wang GJ, Tang X, Fang ZX: A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection. / J Hepatol 2011, 55:1215-221. CrossRef
8. Jiang HX, Han GR, Wang CM, Yue X, Wang GJ: Abstract efficacy of combined vaccine for the prevention of HBV transmission in highly viremic HBeAg-?mothers and the HBV markers-dynamic change of babies in follow-up. / Zhonghua Gan Zang Bing Za Zhi 2011, 19:818-22.
9. Yi W, Li MH, Hu YH, Liu F, Zhang YL, Liu XJ, Hao HX, Song SJ, Liu Y, Li XH, / et al.: Predictive study of HBsAg in different stages of neonatal venous blood on failure of blocking HBV mother to infant transmission. / Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2011, 25:338-41.
10. Wang Z, Zhang J, Yang H, Li X, Wen S, Guo Y, Sun J, Hou J: Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. / J Med Virol 2003, 71:360-66. CrossRef
11. Liu Y, Wang CM, Cheng J, Liang ZL, Zhong YW, Ren XQ, Xu ZH, Zoulim F, Xu DP: Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility. / Chin Med J (Engl) 2009, 122:1585-586.
12. Liu J, Li Y, Chen T, Yang Y, Wang K, He Y, Yang Q, Ye F, Jin Y, Qiu T, / et al.: The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis. / Arch Virol 2008, 153:2157-161. CrossRef
13. Yin YZ, Chen XW, Li XM, Hou HY, Shi ZJ: Intrauterine HBV infection: risk factors and impact of HBV DNA. / Nan Fang Yi Ke Da Xue Xue Bao 2006, 26:1452-454.
14. Zhang SL, Yue YF, Bai GQ, Shi L, Jiang H: Mechanism of intrauterine infection of hepatitis B virus. / World J Gastroenterol 2004, 10:437-38.
15. Guo Y, Liu J, Meng L, Meina H, Du Y: Survey of HBsAg-positive pregnant women and their infants regarding measures to prevent maternal-infantile transmission. / BMC Infect Dis 2010, 10:26. CrossRef
16. Xu DZ, Yan YP, Choi BC, Xu JQ, Men K, Zhang JX, Liu ZH, Wang FS: Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case–control study. / J Med Virol 2002, 67:20-6. CrossRef
17. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/524/prepub - 作者单位：Tianyan Chen (9)
Jing Wang (9)
Yuling Feng (9)
Zhi Yan (9)
Tieying Zhang (9)
Minghui Liu (10)
Yun Bai (11)
Hongxia Song (9)
Hongli Liu (9)
Yuan Yang (9)
Jinfeng Liu (9)
Yingli He (9)
Yunru Chen (9)
Shulin Zhang (9)
Guihua Zhuang (9)
Xiaofeng Liang (12)
Zongyin Liu (13)
Xiaguang Xu (14)
Wei Chen (9)
Yong Liu (9)
Yingren Zhao (9)
9. School of Medicine, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi Province, China
10. Xi’an Hangtian Hospital, Xi’an, Shaanxi, China
11. Shangluo Central Hospital, Shangluo, Shaanxi, China
12. Chinese Center for Disease Control and Prevention, Beijing, China
13. Baoji Maternal and Child Care Service Center, Baoji, Shaanxi, China
14. Ankang Central Hospital, Ankang, Shaanxi, China - ISSN：1471-2334
文摘
Background Neither HBV DNA nor HBsAg positivity at birth is an accurate marker for HBV infection of infants. No data is available for continuous changes of HBV markers in newborns to HBsAg(+) mothers. This prospective, multi-centers study aims at observing the dynamic changes of HBV markers and exploring an early diagnostic marker for mother-infant infection. Methods One hundred forty-eight HBsAg(+) mothers and their newborns were enrolled after mothers signed the informed consent forms. Those infants were received combination immunoprophylaxis (hepatitis B immunoglobulin [HBIG] and hepatitis B vaccine) at birth, and then followed up to 12?months. Venous blood of the infants (0, 1, 7, and 12?months of age) was collected to test for HBV DNA and HBV markers. Results Of the 148 infants enrolled in our study, 41 and 24 infants were detected as HBsAg(+) and HBV DNA(+) at birth, respectively. Nine were diagnosed with HBV infection after 7 mo follow-up. Dynamic observation of the HBV markers showed that HBV DNA and HBsAg decreased gradually and eventually sero-converted to negativity in the non-infected infants, whereas in the infected infants, HBV DNA and HBsAg were persistently positive, or higher at the end of follow-up. At 1 mo, the infants with anti-HBs(+), despite positivity for HBsAg or HBV DNA at birth, were resolved after 12 mo follow-up, whereas all the nine infants with anti-HBs(? were diagnosed with HBV infection. Anti-HBs(? at 1 mo showed a higher positive likelihood ratio for HBV mother-infant infection than HBV DNA and/or HBsAg at birth. Conclusions Negativity for anti-HBs at 1 mo can be considered as a sensitive and early diagnostic indictor for HBV infection in the infants with positive HBV DNA and HBsAg at birth, especially for those infants with low levels of HBV DNA load and HBsAg titer.