Gender impact on the correlations between subclinical thyroid dysfunction and hyperuricemia in Chinese

详细信息    查看全文

• 作者：Jianping Zhang ; Zhaowei Meng ; Qing Zhang ; Li Liu ; Kun Song…
• 关键词：Glomerular filtration rate ; Hyperuricemia ; Serum uric acid ; Subclinical thyroid function disorders
• 刊名：Clinical Rheumatology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：35
• 期：1
• 页码：143-149
• 全文大小：143 KB
• 参考文献：1.Spencer CA, Hollowell JG, Kazarosyan M et al (2007) National Health and Nutrition Examination Survey III thyroid-stimulating hormone (TSH)-thyroperoxidase antibody relationships demonstrate that TSH upper reference limits may be skewed by occult thyroid dysfunction. J Clin Endocrinol Metab 92:4236–4240PubMed CrossRef
  2.Wartofsky L, Dickey RA (2005) The evidence for a narrower thyrotropin reference range is compelling. J Clin Endocrinol Metab 90:5483–5488PubMed CrossRef
  3.Li C, Guan H, Teng X et al (2011) An epidemiological study of the serum thyrotropin reference range and factors that influence serum thyrotropin levels in iodine sufficient areas of China. Endocr J 58:995–1002PubMed CrossRef
  4.Dickey RA, Wartofsky L, Feld S (2005) Optimal thyrotropin level: normal ranges and reference intervals are not equivalent. Thyroid 15:1035–1039PubMed CrossRef
  5.Hollowell JG, Staehling NW, Flanders WD et al (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489–499PubMed CrossRef
  6.Demers LM, Spencer CA (2003) Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf) 58:138–140CrossRef
  7.Baloch Z, Carayon P, Conte-Devolx B et al (2003) Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 13:3–126PubMed CrossRef
  8.Kuzell WC, Schaffarzick RW, Naugler WE et al (1955) Some observations on 520 gouty patients. J Chronic Dis 2:645–669PubMed CrossRef
  9.Kuhlback B (1957) Creatine and creatinine metabolism in thyrotoxicosis and hypothyroidism: a clinical study. Acta Med Scand Suppl 331:1–70PubMed
  10.Leeper RD, Benua RS, Brener JL et al (1960) Hyperuricemia in myxedema. J Clin Endocrinol Metab 20:1457–1466PubMed CrossRef
  11.Bland JH, Frymoyer JW (1970) Rheumatic syndromes of myxedema. N Engl J Med 282:1171–1174PubMed CrossRef
  12.Erickson AR, Enzenauer RJ, Nordstrom DM et al (1994) The prevalence of hypothyroidism in gout. Am J Med 97:231–234PubMed CrossRef
  13.Montenegro J, Gonzalez O, Saracho R et al (1996) Changes in renal function in primary hypothyroidism. Am J kidney Dis : Off J Natl Kidney Found 27:195–198CrossRef
  14.Mooraki A, Bastani B (1998) Reversible renal insufficiency, hyperuricemia and gouty arthritis in a case of hypothyroidism. Clin Nephrol 49:59–61PubMed
  15.Makino Y, Fujii T, Kuroda S et al (2000) Exacerbation of renal failure due to hypothyroidism in a patient with ischemic nephropathy. Nephron 84:267–269PubMed CrossRef
  16.Dumitriu L, Bartoc R, Ursu H et al (1988) Significance of high levels of serum malonyl dialdehyde (MDA) and ceruloplasmin (CP) in hyper- and hypothyroidism. Endocrinologie 26:35–38PubMed
  17.Ford HC, Lim WC, Chisnall WN et al (1989) Renal function and electrolyte levels in hyperthyroidism: urinary protein excretion and the plasma concentrations of urea, creatinine, uric acid, hydrogen ion and electrolytes. Clin Endocrinol (Oxf) 30:293–301CrossRef
  18.Shirota T, Shinoda T, Yamada T et al (1992) Alteration of renal function in hyperthyroidism: increased tubular secretion of creatinine and decreased distal tubule delivery of chloride. Metabolism 41:402–405PubMed CrossRef
  19.Sato A, Shirota T, Shinoda T et al (1995) Hyperuricemia in patients with hyperthyroidism due to Graves’ disease. Metabolism 44:207–211PubMed CrossRef
  20.Giordano N, Santacroce C, Mattii G et al (2001) Hyperuricemia and gout in thyroid endocrine disorders. Clin Exp Rheumatol 19:661–665PubMed
  21.Yazar A, Doven O, Atis S et al (2003) Systolic pulmonary artery pressure and serum uric acid levels in patients with hyperthyroidism. Arch Med Res 34:35–40PubMed CrossRef
  22.Zhang Q, Lou S, Meng Z et al (2011) Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese. Clin Rheumatol 30:777–787PubMed CrossRef
  23.Liu L, Lou S, Xu K et al (2013) Relationship between lifestyle choices and hyperuricemia in Chinese men and women. Clin Rheumatol 32:233–239PubMed CrossRef
  24.Goncalves JP, Oliveira A, Severo M et al (2012) Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome. Endocrine 41:450–457PubMed CrossRef
  25.Doghramji PP, Wortmann RL (2012) Hyperuricemia and gout: new concepts in diagnosis and management. Postgrad Med 124:98–109PubMed CrossRef
  26.Hamburger M, Baraf HS, Adamson TC 3rd et al (2011) 2011 Recommendations for the diagnosis and management of gout and hyperuricemia. Postgrad Med 123:3–36PubMed CrossRef
  27.Al-Arfaj AS (2001) Hyperuricemia in Saudi Arabia. Rheumatol Int 20:61–64PubMed CrossRef
  28.Ma YC, Zuo L, Chen JH et al (2006) Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17:2937–2944PubMed CrossRef
  29.Arora S, Chawla R, Tayal D et al (2009) Biochemical markers of liver and kidney function are influenced by thyroid function-a case-controlled follow up study in Indian hypothyroid subjects. Indian J Clin Biochem 24:370–374PubMed PubMedCentral CrossRef
  30.Allon M, Harrow A, Pasque CB et al (1990) Renal sodium and water handling in hypothyroid patients: the role of renal insufficiency. J Am Soc Nephrol : JASN 1:205–210PubMed
  31.Raber W, Vukovich T, Vierhapper H (1999) Serum uric acid concentration and thyroid-stimulating-hormone (TSH): results of screening for hyperuricaemia in 2359 consecutive patients with various degrees of thyroid dysfunction. Wien Klin Wochenschr 111:326–328PubMed
  32.Lippi G, Montagnana M, Targher G et al (2008) Relationship between thyroid status and renal function in a general population of unselected outpatients. Clin Biochem 41:625–627PubMed CrossRef
  33.Nan H, Qiao Q, Dong Y et al (2006) The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China. J Rheumatol 33:1346–1350PubMed
  34.Akizuki S (1982) Serum uric acid levels among thirty-four thousand people in Japan. Ann Rheum Dis 41:272–274PubMed PubMedCentral CrossRef
  35.Sumino H, Ichikawa S, Kanda T et al (1999) Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia. Lancet 354:650PubMed CrossRef
  36.Hak AE, Choi HK (2008) Menopause, postmenopausal hormone use and serum uric acid levels in US women–the Third National Health and Nutrition Examination Survey. Arthritis Res Ther 10:R116PubMed PubMedCentral CrossRef
  37.Anton FM, Garcia Puig J, Ramos T et al (1986) Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17 beta (E2) on the renal handling of urate. Metabolism 35:343–348PubMed CrossRef
  38.Yahyaoui R, Esteva I, Haro-Mora JJ et al (2008) Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons. J Clin Endocrinol Metab 93:2230–2233PubMed CrossRef
  
• 作者单位：Jianping Zhang (1)
  Zhaowei Meng (1)
  Qing Zhang (2)
  Li Liu (2)
  Kun Song (2)
  Jian Tan (1)
  Xue Li (1)
  Qiang Jia (1)
  Guizhi Zhang (1)
  Yajing He (1)
  
  1. Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin, People’s Republic of China
  2. Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  
• 出版者：Springer London
• ISSN：1434-9949

文摘

Overt hypothyroidism and hyperthyroidism can lead to hyperuricemia. However, few data are available regarding the association between subclinical thyroid dysfunction and hyperuricemia, especially from the perspective of gender impact. This study aimed to investigate the association between subclinical thyroid disorders and hyperuricemia with emphasized focuses on differences resulting from different gender. Eleven thousand four hundred forty-six healthy subjects (6870 male, 4576 female) were enrolled in this cross-sectional study, with exclusions of known thyroid, renal, hepatic, gastrointestinal, or oncological diseases. Clinical data including anthropometric measurements, thyroid function, uric acid, renal and liver function were collected. The associations between thyroid function and hyperuricemia of males and females were analyzed separately. Prevalence of hyperuricemia was substantially higher in male (23.17 %) than that in female (9.11 %). Serum uric acid was correlated well with various factors, especially with creatinine, whose coefficients were 0.283 and 0.386 for males and females. The significantly elevated risk for hyperuricemia was observed in mild hypothyroidism male participants with an odd ratio of 1.49 (1.10–2.02), whereas no statistical risk was found in female. No meaningful risk was found in mild hyperthyroidism participants. Estimated glomerular filtration rate was significantly depressed in both genders with mild hypothyroidism, while obviously increased in both genders with mild hyperthyroidism. For hyperuricemia, mild hypothyroidism is a risk factor in males while it is not in females. This difference could be caused by the protective effect of estrogen in females. Monitoring serum uric acid in subclinical hypothyroidism is more necessary in males.