Characterization of solitary pulmonary nodules with 18F-FDG PET/CT relative activity distribution analysis

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• 作者：Liang Zhao ; Li Tong ; Jie Lin ; Kun Tang ; SiSi Zheng ; WenFeng Li…
• 关键词：Solitary pulmonary nodule ; Fluorodeoxyglucose F18 ; Positron emission tomography ; Sensitivity and specificity ; ROC curve
• 刊名：European Radiology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：25
• 期：7
• 页码：1837-1844
• 全文大小：2,670 KB
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• 作者单位：Liang Zhao (1)
  Li Tong (2)
  Jie Lin (1)
  Kun Tang (1)
  SiSi Zheng (1)
  WenFeng Li (3)
  DeZhi Cheng (4)
  WeiWei Yin (1)
  XiangWu Zheng (1)
  
  1. Division of PET/CT, Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 325000
  2. CT Department, The First People’s Hospital of Hefei, Hefei, China
  3. Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  4. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objectives To compare the capability of relative activity distribution (RAD), a new index of fluorodeoxyglucose F18 (18F-FDG) uptake, with those of the typical markers for differentiating benign and malignant solitary pulmonary nodules (SPNs) by integrated positron emission tomography (PET)/computed tomography (CT). Methods RAD, maximal standardised uptake value (SUV_max), partial volume corrected SUV_max (corrSUV_max), and retention index (RI) were calculated prospectively for 115 malignant and 60 benign SPNs. Area under receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy were compared (P-lt;-.05). Results Malignant lesions (0.98?±-.03) had significantly lower RAD than benign lesions (1.01?±-.02). AUC (0.935) was significantly larger and specificity (96.67?%) was significantly higher for RAD than for SUV_max (P?≤-.0001), corrSUV_max (P-lt;-.0001), RI (P-lt;-.0001), and visual assessment (P--.01 and 0.002, respectively). Further, RAD had significantly higher sensitivity (92.17?%) than SUV_max (P--.0007) and higher accuracy (93.71?%) than SUV_max (P-lt;-.0001), corrSUV_max (P-lt;-.0001), and RI (P--.002). Conclusions RAD seems to be more specific and accurate than the typical markers for differentiating malignant and benign SPNs by 18F-FDG PET/CT. Key Points -Relative activity distribution index is assessable by 18 F-FDG PET/CT -The index effectively characterises solitary pulmonary nodules -RAD is more specific and accurate than the typical markers in 18 F-FDG PET/CT -RAD provides additional options for small solitary pulmonary nodules