Recent advances of adapter proteins in the regulation of heart diseases
详细信息 查看全文
- 作者：Li Tao ; Linna Jia ; Yuntian Li ; Chengyun Song ; Zheng Chen
- 关键词：Adapter protein ; Insulin signaling ; Inflammation ; Heart diseases
- 刊名：Heart Failure Reviews
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：22
- 期：1
- 页码：99-107
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Cardiology;
- 出版者：Springer US
- ISSN：1573-7322
- 卷排序：22
文摘
Heart diseases are major causes of mortality. Cardiac hypertrophy, myocardial infarction (MI), viral cardiomyopathy, ischemic and reperfusion (I/R) heart injury finally lead to heart failure and death. Insulin and IGF1 signal pathways play key roles in normal cardiomyocyte growth and physiological cardiac hypertrophy while inflammatory signal pathway is associated with pathological cardiac hypertrophy, MI, viral cardiomyopathy, I/R heart injury, and heart failure. Adapter proteins are the major family proteins, which transduce signals from insulin, IGF1, or cytokine receptors to the downstream pathways and have been shown to regulate variety of heart diseases. Here, we summarized the recent advances in understanding the physiological and pathological roles of adapter proteins in heart failure.