Response–Dose Ratio is a Surrogate of Cumulative Provocative Dosage for Bronchial Provocation Tests in Asthma

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• 作者：Wei-jie Guan ; Jin-ping Zheng ; Xu Shi ; Yan-qing Xie ; Cai-yu Jiang ; Yi Gao ; Zheng Zhu…
• 关键词：Response–dose ratio ; Cumulative provocative dosage ; Asthma ; Leukotriene D4 ; Methacholine
• 刊名：Lung
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：192
• 期：5
• 页码：701-709
• 全文大小：245 KB
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• 作者单位：Wei-jie Guan (1)
  Jin-ping Zheng (1)
  Xu Shi (1)
  Yan-qing Xie (1)
  Cai-yu Jiang (1) (2)
  Yi Gao (1)
  Zheng Zhu (1)
  Jia-ying An (1)
  Xin-xin Yu (1)
  Wen-ting Liu (1)
  
  1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, China
  2. Sichuan People’s Hospital, Chengdu, Sichuan, China
  
• ISSN：1432-1750

文摘

Background Response–dose ratio (RDR) and cumulative provocative dosage (PD) are useful indices reflecting airway responsiveness in asthma. Objectives To compare the diagnostic value of RDR and PD, by conducting leukotriene D4 (LTD4-BPT) and methacholine bronchial provocation test (MCh-BPT), in different asthma control levels. Methods Healthy subjects and asthmatic patients underwent LTD4-BPT and MCh-BPT, at 2-4-day interval. This entailed assessment of the distribution characteristics, correlation, and diagnostic value of PD inducing 20?% fall in forced expiratory volume in one second (PD20FEV1) and the RDR, defined as FEV1 fall (%) at the final step divided by the corresponding provocative dosage. Results Twenty uncontrolled, 22 partly controlled, 20 controlled asthmatics, and 21 healthy subjects were enrolled. Log10RDR was positively correlated with log10PD20FEV1 in both BPTs (all P?20FEV1 and higher RDR (both P?20FEV1 and RDR between partly controlled and controlled asthma were unremarkable (both P?>?0.05). Compared with log10PD20FEV1, the log10RDR yielded similar diagnostic values in both BPTs. A lower percentile of RDR (?5th percentile) was associated with higher baseline FEV1 (P?20FEV1 led to an increased diagnostic value compared with either parameter alone. Conclusions RDR is a surrogate of PD20FEV1 for BPTs in asthma. This finding was not modified by different asthma control levels or the types of bronchoprovocants.