Clinical Significance of Anti-HEV IgA in Diagnosis of Acute Genotype 4 Hepatitis E Virus Infection Negative for Anti-HEV IgM

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• 作者：Shujun Zhang ; Deying Tian ; Zhengang Zhang ; Junhui Xiong ; Quan Yuan ; Shengxiang Ge ; Jun Zhang and Ningshao Xia
• 关键词：Hepatitis E virus ; Acute hepatitis E ; Anti ; HEV IgA ; Anti ; HEV IgM ; Anti ; HEV IgG
• 刊名：Digestive Diseases and Sciences
• 出版年：2009
• 出版时间：November, 2009
• 年：2009
• 卷：54
• 期：11
• 页码：2512-2518
• 全文大小：177.1 KB

文摘

Anti-HEV IgM is a diagnostic for recent or ongoing HEV infection. However, some patients with acute hepatitis E (AHE) negative for anti-HEV IgM in acute period were often observed in clinical practice. In this study, we constructed the anti-HEV IgA indirect ELISA assay to evaluate the significance of anti-HEV IgA. The specificity of anti-HEV IgA was 99.6 % . Among 245 AHE patients, 84 samples from 84 patients were positive for HEV RNA. The positive rate of anti-HEV IgA, anti-HEV IgM and anti-HEV IgG in 84 samples positive for HEV RNA was 96.3, 97.6, and 88.1 % , respectively, and no sample was negative for anti-HEV IgA and anti-HEV IgM simultaneously. Among 245 AHE patients, we found nine samples collected from nine patients in acute period were negative for anti-HEV IgM but positive for anti-HEV IgA and two samples were positive for HEV RNA. Detection of anti-HEV IgA can be a useful supplement for diagnosis of acute HEV infection especially in patients negative for anti-HEV IgM.