Enhancement of immunological activity of CpG ODN by chitosan gene carrier
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- 作者：Yi Xiang (1)
Qingsong Yu (2)
Zhi Qi (1)
Zhengde Du (2)
Shunqing Xu (3)
Huafeng Zhang (1) - 关键词：chitosan ; CpG ODN ; gene carrier ; mice ; immunocompetence
- 刊名：Journal of Huazhong University of Science and Technology [Medical Sciences]
- 出版年：2007
- 出版时间：April 2007
- 年：2007
- 卷：27
- 期：2
- 页码：128-130
- 全文大小：70KB
- 参考文献：1. Krieg A M. Immune effects and mechanisms of action of CpG motifs. Vaccine, 2000,19:618-22 CrossRef
2. Chu R S, Targoni O S, Krieg A M / et al. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med, 1997,186:1623-631 CrossRef
3. Richardson S C W, Kolbe H V J, Duncan R. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int J Pharm, 1999,178:231-43 CrossRef
4. Jameela S R, Kumary T V, Lal A V / et al. Progesterone loaded chitosan microspheres: a long acting biodegradable controlled delivery system. J Controlled Release, 1998, 52(1/2):17-4 CrossRef
5. Krieg A M, Yi A K, Matson S / et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature, 1995, 347(6522):546-49 CrossRef
6. Parwasser, R M. Vabulas B, Villmow G B / et al. Bacterial CpG-DNA activates dendritic cells / in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur J Immunol, 2000,30:3591-597 CrossRef
7. Ballas Z K, Rasmussen W L, Krieg A M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol, 1996, 157:1840-845
8. Elkins K L, Rhinehart T R, Stibitz S / et al. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol, 1999,162:2291-298
9. Weiner G J, Liu H M, Wooldridge J E / et al. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci, 1997,94:10833-0837 CrossRef
10. Chu R S, Targoni O S, Krieg A M / et al. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med, 1997,186:1623-631 CrossRef
11. Fang N, Chan V, Mao H Q / et al. Interactions of phospholipids bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules, 2001,2(4):1161-168 CrossRef
12. Cui Z, Mumper R J. Chitosan-based nanoparticles for topical genetic immunization. J Control Release, 2001,75:409-19 CrossRef - 作者单位：Yi Xiang (1)
Qingsong Yu (2)
Zhi Qi (1)
Zhengde Du (2)
Shunqing Xu (3)
Huafeng Zhang (1)
1. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
2. Department of ENT, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China
3. Department of Environmental Medicine, School of Public Health, Huazhong University of Science and Technology, Wuhan, 430022, China
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