Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal cancer in vitro and in vivo

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• 作者：Bingfei Xu ; Yu Wang ; Jing Yang ; Zhengfeng Zhang…
• 关键词：Apoptosis ; Celecoxib ; ER stress ; Human colorectal cancer ; VEGF
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：77
• 期：4
• 页码：797-806
• 全文大小：1,259 KB
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• 作者单位：Bingfei Xu (2)
  Yu Wang (3)
  Jing Yang (4)
  Zhengfeng Zhang (3)
  Ying Zhang (3)
  Hansong Du (1)
  
  2. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
  3. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
  4. Department of Infectious Disease, Renmin Hospital, Hubei University of Medicine, Shiyan, People’s Republic of China
  1. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430030, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Pharmacology and Toxicology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0843

文摘

Purpose In our previous study, we found that celecoxib, a kind of COX-2 inhibitor, led to cell apoptosis while up-regulating the expression of vascular endothelial growth factor (VEGF) in colorectal cancer HCT116 cells (COX-2 deficient), and endoplasmic reticulum (ER) stress was involved in the mechanism. Thus, we would like to explore whether these results are universal for other colorectal cancer cells, especially for COX-2-expressing ones, and whether the results in vitro and in vivo are matched.