Levels of Heavy Metals and Trace Elements in Umbilical Cord Blood and the Risk of Adverse Pregnancy Outcomes: a Population-Based Study
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- 作者：Guanchao Zheng (1)
Hongxiu Zhong (2)
Zhizhun Guo (1)
Zhuangchu Wu (3)
Huaiqing Zhang (3)
Chonggang Wang (1)
Yulin Zhou (2)
Zhenghong Zuo (1) - 关键词：Adverse pregnancy outcomes ; Umbilical cord blood ; Heavy metals and trace elements
- 刊名：Biological Trace Element Research
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：160
- 期：3
- 页码：437-444
- 全文大小：165 KB
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Hongxiu Zhong (2)
Zhizhun Guo (1)
Zhuangchu Wu (3)
Huaiqing Zhang (3)
Chonggang Wang (1)
Yulin Zhou (2)
Zhenghong Zuo (1)
1. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China
2. Prenatal Diagnosis Center of Xiamen, Maternal and Child Health Hospital of Xiamen, Xiamen, 361003, China
3. School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China - ISSN：1559-0720
文摘
To better understand the relationship between prenatal exposure to heavy metals and trace elements and the risk of adverse pregnancy outcomes, we investigated the status of heavy metals and trace elements level in a Chinese population by collecting umbilical cord blood. Umbilical cord blood heavy metals and trace elements concentrations were determined by inductively coupled plasma–mass spectrometry. No differences with statistical significance in the median arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), strontium (Sr), thallium (Tl), vanadium (V), and zinc (Zn) concentrations were observed between the adverse pregnancy outcome group and the reference group. Titanium (Ti) and antimony (Sb) were found at higher levels with statistical significance in the cord blood samples with adverse pregnancy group when compared to the ones in the reference group. The association between Ti levels and the risk of adverse pregnancy outcomes remained significant after adjusting for potential confounding factors, including newborn weight. These results indicated that environmental exposure to Ti may increase the risk of adverse pregnancy outcomes in Chinese women without occupational exposure.