Mung Bean Decreases Plasma Cholesterol by Up-regulation of CYP7A1
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- 作者：Yang Yao (1)
Liu Hao (1)
Zhenxing Shi (1)
Lixia Wang (1)
Xuzhen Cheng (1)
Suhua Wang (1)
Guixing Ren (1) - 关键词：Cholesterol ; CYP7A1 ; HMG ; CoA reductase ; Mung bean
- 刊名：Plant Foods for Human Nutrition
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：69
- 期：2
- 页码：134-136
- 全文大小：
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Liu Hao (1)
Zhenxing Shi (1)
Lixia Wang (1)
Xuzhen Cheng (1)
Suhua Wang (1)
Guixing Ren (1)
1. Institute of Crop Science, Chinese Academy of Agricultural Sciences, No.80 South Xueyuan Road, Haidian District, Beijing, 100081, People鈥檚 Republic of China - ISSN：1573-9104
文摘
Our results affirmed that supplementation of 1 or 2聽% mung bean could decrease plasma total cholesterol and triacylglycerol level. Mung bean increased mRNA 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Most importantly, mung bean increased not only the protein level of cholesterol-7伪-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of mung bean was most probable mediated by enhancement of bile acid excretion and up-regulation of CYP7A1.