Case-control study of GRIA1 and GRIA3 gene variants in migraine

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• 作者：Jie Fang ; Xingkai An ; Shuai Chen ; Zhenzhen Yu ; Qilin Ma…
• 关键词：Migraine ; GRIA1 ; GRIA3 ; Gene variant ; Glutamate
• 刊名：The Journal of Headache and Pain
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：403 KB
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• 作者单位：Jie Fang (1)
  Xingkai An (1)
  Shuai Chen (2)
  Zhenzhen Yu (1)
  Qilin Ma (1) (2)
  Hongli Qu (1)
  
  1. Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China
  2. The First Clinical Medical College of Fujian Medical University, Fuzhou, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pain Medicine
  Internal Medicine
  Neurology
  
• 出版者：Springer Milan
• ISSN：1129-2377

文摘

Background As the most abundant excitatory neurotransmitter in the central nervous system, glutamate has been accepted to play a major role in the pathophysiology of migraine. The previous studies have reported the glutamate receptor ionotropic GRIA1 and GRIA3 genes variants associated with migraine. The project aims to investigate the polymorphisms in both genes for their association with migraine in the Chinese Han population.