Dioxin and Dioxin-Like Compounds Suppress Acetylcholinesterase Activity via Transcriptional Downregulations In Vitro
详细信息 查看全文
- 作者：Hai-Ming Xu (1)
Heidi Qunhui Xie (1)
Wu-Qun Tao (1)
Zhi-Guang Zhou (1)
Shuai-Zhang Li (1)
Bin Zhao (1) - 关键词：Acetylcholinesterase (AChE) ; Aryl hydrocarbon receptor (AhR) ; Dioxin ; responsive element (DRE) ; Dioxin ; Transcriptional regulation ; Neuron
- 刊名：Journal of Molecular Neuroscience
- 出版年：2014
- 出版时间：July 2014
- 年：2014
- 卷：53
- 期：3
- 页码：417-423
- 全文大小：500 KB
- 参考文献：1. Ahmed M, Rocha JBT, Mazzanti CM et al (2007) Malathion, carbofuran and paraquat inhibit / Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro. Ecotoxicology 16:363-69 CrossRef
2. Ahmed M, Latif N, Khan RA, Ahmad A (2012) Toxicological effect of herbicides (diuron and bentazon) on snake venom and electric eel acetylcholinesterase. Bull Environ Contam Toxicol 89:229-33 CrossRef
3. Ahmed RG (2011) Perinatal TCDD exposure alters developmental neuroendocrine system. Food Chem Toxicol 49:1276-284 CrossRef
4. Behnisch PA, Hosoe K, Sakai S (2003) Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds. Environ Int 29:861-77 CrossRef
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-54 CrossRef
6. Bronicki LM, Jasmin BJ (2012) Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons. Front Mol Neurosci 5:36 CrossRef
7. Denison MS, Nagy SR (2003) Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-34 CrossRef
8. Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-5 CrossRef
9. Fleschjanys D, Berger J, Gurn P et al (1995) Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. Am J Epidemiol 142:1165-175
10. Fulton MH, Key PB (2001) Acetylcholinesterase inhibition in estuarine fish and invertebrates as an indicator of organophosphorus insecticide exposure and effects. Environ Toxicol Chem 20:37-5 CrossRef
11. Hayakawa K, Takatsuki H, Watanabe I, Sakai S (2004) Polybrominated diphenyl ethers (PBDEs), polybrominated dibenzo-p-dioxins/dibenzofurans (PBDD/Fs) and monobromo-polychlorinated dibenzo-p-dioxins/dibenzofurans (MoBPXDD/Fs) in the atmosphere and bulk deposition in Kyoto, Japan. Chemosphere 57:343-56 CrossRef
12. Li H, Yu L, Sheng G, Fu J, Peng PA (2007) Severe PCDD/F and PBDQ/F pollution in air around an electronic waste dismantling area in China. Environ Sci Technol 41:641-646
13. Litten S, McChesney DJ, Hamilton MC, Fowler B (2003) Destruction of the World Trade Center and PCBs, PBDEs, PCDD/Fs, PBDD/Fs, and chlorinated biphenylenes in water, sediment, and sewage sludge. Environ Sci Technol 37:5502-510 CrossRef
14. Massoulié J (2002) The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals 11:130-43 CrossRef
15. Mdegela RH, Mosha RD, Sandvik M, Skaare JU (2010) Assessment of acetylcholinesterase activity in / Clarias gariepinus as a biomarker of organophosphate and carbamate exposure. Ecotoxicology 19:855-63 CrossRef
16. Olsman H, Engwall M, Kammann U et al (2007) Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-p-dioxins and -furans in cell lines from four different species. Environ Toxicol Chem 26:2448-454 CrossRef
17. Richetti SK, Rosemberg DB, Ventura-Lima J, Monserrat JM, Bogo MR, Bonan CD (2011) Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure. Neurotoxicology 32:116-22 CrossRef
18. Sailaja BS, Cohen-Carmon D, Zimmerman G, Soreq H, Meshorer E (2012) Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc Natl Acad Sci U S A 109:e3687–e3695 CrossRef
19. Schecter A, Birnbaum L, Ryan JJ, Constable JD (2006) Dioxins: an overview. Environ Res 101:419-28 CrossRef
20. Shaltiel G, Hanan M, Wolf Y et al (2013) Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target. Brain Struct Funct 218:59-2 CrossRef
21. Soreq H, Seidman S (2001) Acetylcholinesterase—new roles for an old actor. Nat Rev Neurosci 2:294-02 CrossRef
22. Van den Berg M, Birnbaum LS, Denison MS et al (2006) The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93:223-41 CrossRef
23. Van den Berg M, Denison MS, Birnbaum LS et al (2013) Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. Toxicol Sci 133:197-08 CrossRef
24. Velan B, Kronman C, Ordentlich A et al (1993) N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis. Biochem J 296:649-56
25. Wang LC, Hsi HC, Wang YF, Lin SL, Chang-Chien GP (2010) Distribution of polybrominated diphenyl ethers (PBDEs) and polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) in municipal solid waste incinerators. Environ Pollut 158:1595-602 CrossRef
26. Wang ZY, Zhao J, Li FM, Gao DM, Xing BS (2009) Adsorption and inhibition of acetylcholinesterase by different nanoparticles. Chemosphere 77:67-3 CrossRef
27. WHO (2010) Dioxins and their effects on human health. Fact sheet 225.
28. Winer J, Jung CKS, Shackel I, Williams PM (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270:41-9 CrossRef
29. Xie HQ, Xu HM, Fu HL et al (2013) AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro. Environ Health Perspect 121:613-18 - 作者单位：Hai-Ming Xu (1)
Heidi Qunhui Xie (1)
Wu-Qun Tao (1)
Zhi-Guang Zhou (1)
Shuai-Zhang Li (1)
Bin Zhao (1)
1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China - ISSN：1559-1166
文摘
Recently, acetylcholinesterase (AChE, EC 3.1.1.7) has received increased attention in the field of environmental sciences. Evaluation of the effects of environmental contaminants on AChE enzymatic activity not only can reflect, to some extent, the interference with the nervous system, but also can be used for monitoring pollution. Our previous study showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) suppressed neuronal AChE enzymatic activity via transcriptional downregulations mediated by aryl hydrocarbon receptor. In the present study, the effects of several other dioxin-like compounds (DLCs) on neuronal AChE activity were determined, including 1,2,3,7,8-pentachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrabromodibenzo-p-dioxin. The results showed that the enzymatic activity of AChE was significantly decreased by approximately 15-0?% after exposure to a certain concentrations of the DLCs, whereas incubating neuronal cell lysates directly with these DLCs did not inhibit AChE enzyme. Subsequent molecular mechanism study showed that these chemicals could decrease ACHE promoter activity, as well as AChE T mRNA expression, thereby suggesting the involvements of transcriptional regulation in these effects. These findings on DLCs are similar with those on 2,3,7,8-TCDD, pointing to the possibility that exposure to dioxin and DLCs, which frequently coexist in the contaminated environments, may concurrently interfere with the cholinergic functions via AChE.