The Role of Phosphorylated Cx43 on PKC Mediated Ser368 in Lung Injury Induced by Seawater Inhalation

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• 作者：Tonggang Liu ; Yanyan Li ; Bo Zhang ; Lijie Ma ; Wei Liu ; Zhichao Li…
• 关键词：seawater ; ALI ; Connexin43 ; PKC
• 刊名：Inflammation
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：38
• 期：5
• 页码：1847-1854
• 全文大小：635 KB
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• 作者单位：Tonggang Liu (1)
  Yanyan Li (1)
  Bo Zhang (2)
  Lijie Ma (1)
  Wei Liu (1)
  Zhichao Li (2)
  Faguang Jin (1)
  
  1. Department of Respiratory Medicine, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China
  2. Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi’an, Shaanxi, 710032, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Seawater aspiration may result in acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which is characterized by pulmonary inflammation and lung edema that closely related to pulmonary barrier dysfunction and intracellular communication. The aim of the present research was to explore the role of connexion 43 (Cx43) in seawater aspiration-induced ALI/ARDS. The results from in vivo experiments showed that seawater inhalation led to increased expression of p-PKC and phosphorylated Cx43 (p-Cx43), which were followed by protein rich fluid leakage and TNF-α and IL-1β secretion. Besides, the results from in vitro tests proved that the expression of p-PKC directly influenced phosphorylation state of Cx43 and its function, which could further affect the inflammatory factors secretion and intercellular communication. In conclusion, seawater aspiration causes p-Cx43 expression by PKC pathway, which is involved in the on come and development of pulmonary inflammation and lung edema. KEY WORDS seawater ALI Connexin43 PKC