Recent advances in preimplantation genetic diagnosis and screening

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• 作者：Lina Lu ; Bo Lv ; Kevin Huang ; Zhigang Xue…
• 关键词：Preimplantation genetic diagnosis (PGD) ; Preimplantation genetic screening (PGS) ; In vitro fertilization (IVF) ; Embryo biopsy ; Non ; invasive testing
• 刊名：Journal of Assisted Reproduction and Genetics
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：33
• 期：9
• 页码：1129-1134
• 全文大小：307 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Developmental Biology
  Human Genetics
  
• 出版者：Springer Netherlands
• ISSN：1573-7330
• 卷排序：33

文摘

Preimplantation genetic diagnosis/screening (PGD/PGS) aims to help couples lower the risks of transmitting genetic defects to their offspring, implantation failure, and/or miscarriage during in vitro fertilization (IVF) cycles. However, it is still being debated with regard to the practicality and diagnostic accuracy of PGD/PGS due to the concern of invasive biopsy and the potential mosaicism of embryos. Recently, several non-invasive and high-throughput assays have been developed to help overcome the challenges encountered in the conventional invasive biopsy and low-throughput analysis in PGD/PGS. In this mini-review, we will summarize the recent progresses of these new methods for PGD/PGS and discuss their potential applications in IVF clinics.