Influence of Val108/158Met COMT Gene Polymorphism on the Efficacy of Modified Electroconvulsive Therapy in Patients with Treatment Resistant Depression

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• 作者：Zhaoyu Lin ; Hongbo He ; Chunping Zhang ; Zhijie Wang…
• 关键词：Treatment resistant depression ; Catechol ; O ; methyltransferase gene ; Gene polymorphism ; Modified electroconvulsive therapy ; Hamilton Depression Rating Scale for Depression
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：71
• 期：3
• 页码：1387-1393
• 全文大小：637 KB
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• 作者单位：Zhaoyu Lin (1)
  Hongbo He (1)
  Chunping Zhang (1)
  Zhijie Wang (1)
  Miaoling Jiang (1)
  Qirong Li (1)
  Xiaochang Lan (1)
  Minling Zhang (1)
  Xiong Huang (1)
  
  1. Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical University, 36 Mingxin Rd, Liwan District, Guangzhou, 510370, People鈥檚 Republic of China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

Depression is a common emotional disorder associated with increased risk of suicide and rate of disability. In this double-blinded control study, we tested the efficacy of modified electroconvulsive therapy (MECT) in patients with treatment resistant depression (TRD) using the Hamilton Depression Rating Scale for Depression (HAMD). The total scores of HAMD were found to be significantly decreased after the treatment. The genotyping of catechol-O-methyltransferase (COMT) was carried out with polymerase chain reaction-based testing. Our results demonstrated that frequency of mutant COMT alleles in TRD patients was significantly higher than that of the controls indicating a correlation of the enzyme genotype to the occurrence of TRD. Moreover, the patients homozygous for wild-type COMT gene (G/G) were evidenced to be more sensitive to MECT treatment than those with an heterozygous mutant genotype (A/G).