Primary Esophageal CD30-Positive ALK-Positive Anaplastic Large Cell Lymphoma: A Case Report and Literature Review

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• 作者：Ning Wu (1)
  Liewen Pang (1)
  Zhiming Chen (1)
  Yiqing Wang (1)
  Qinyun Ma (1)
  Gang Chen (1)
  Ji Chen (1)
  Jiechun Huang (1)
  
• 关键词：esophageal lymphoma ; anaplastic large cell lymphoma ; CD30 ; positive ; ALK ; positive
• 刊名：Journal of Gastrointestinal Cancer
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：42
• 期：1
• 页码：57-60
• 全文大小：311KB
• 参考文献：1. Stein H, Mason DY, Gerdes J, et al. The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed–Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985;66:848-8.
  2. Delsol G, Ralfkiaer E, Sein H, et al. Anaplastic large cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumours. Lyon: IARC; 2001. p. 230-.
  3. Herrmann R, Panahon AM, Barcos MP, et al. Gastrointestinal involvement in non-Hodgkin’s lymphoma. Cancer. 1980;46:215-2. CrossRef
  4. Rosenberg SA, Diamond HD, Jaslowitz B, et al. Lymphosarcoma: a review of 1269 cases. Medicine (Baltimore). 1961;40:31-3. CrossRef
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  8. Doki T, Hamada S, Murayama H, et al. Primary malignant lymphoma of the esophagus. A case report. Endoscopy. 1984;16:189-2. CrossRef
  9. Stein H, Foss HD, Durkop H, et al. CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood. 2000;96:3681-5.
  10. Mary A, Jennifer S, Sarah E, et al. Different gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum Pathol. 2005;36:494-04. CrossRef
  11. Sicinska E, Aifantis I, Le Dam L, et al. Requirements for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003;4:451-1. CrossRef
  
• 作者单位：Ning Wu (1)
  Liewen Pang (1)
  Zhiming Chen (1)
  Yiqing Wang (1)
  Qinyun Ma (1)
  Gang Chen (1)
  Ji Chen (1)
  Jiechun Huang (1)
  
  1. Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China
  
• ISSN：1941-6636

文摘

Purpose To introduce a case of primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma (ALCL) and discuss its diagnosis and treatment. Methods Esophagectomy was done for a 37-year-old male with a submucosal lesion after a frozen section failed to give a definite diagnosis. Samples were sent for hematoxylin–eosin staining and immunohistochemical analysis. Six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy were given and the patient was followed up. Results The operation was uneventful. Postoperative pathologic and immunohistochemical examination yielded a diagnosis of primary CD30-positive and ALK-positive ALCL of the esophagus. The patient was in complete remission at the 14-month follow-up. Conclusions ALCL of the esophagus should be considered in the differential diagnosis of esophageal submucosal lesions. Biopsy through either esophagoscopy or surgical exploration, chemotherapy, and radiotherapy can be chosen for long-term survival.