The tumor suppressor role of PAQR3 in osteosarcoma
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- 作者：Zhiqiang Ma ; Yanlong Wang ; Taikui Piao ; Zhaopeng Li ; Hongyu Zhang…
- 关键词：Osteosarcoma ; Tumor suppressor ; PAQR3 ; ERK1/2
- 刊名：Tumor Biology
- 出版年：2015
- 出版时间：May 2015
- 年：2015
- 卷：36
- 期：5
- 页码：3319-3324
- 全文大小：2,230 KB
- 参考文献：1.Rainusso N, Wang LL, Yustein JT. The adolescent and young adult with cancer: State of the art bone tumors. Curr Oncol Rep. 2013;15:296鈥?07.View Article PubMed
2.Namlos HM, Meza-Zepeda LA, Baroy T, Ostensen IH, Kresse SH, Kuijjer ML, et al. Modulation of the osteosarcoma expression phenotype by micrornas. PLoS One. 2012;7:e48086.View Article PubMed Central PubMed
3.Zhao H, Guo M, Zhao G, Ma Q, Ma B, Qiu X, et al. Mir-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of ezrin in f5m2 cells. Int J Mol Med. 2012;30:1013鈥?0.PubMed Central PubMed
4.Yang J, Zhang W. New molecular insights into osteosarcoma targeted therapy. Curr Opin Oncol. 2013;25:398鈥?06.View Article PubMed
5.Cai H, Lin L, Tang M, Wang Z. Prognostic evaluation of microrna-210 expression in pediatric osteosarcoma. Med Oncol. 2013;30:499.View Article PubMed
6.Chung JY, Kim JD, Park GH, Jung ST, Lee KB: Occipito-cervical reconstruction through direct lateral and posterior approach or the treatment of primary osteosarcoma in the atlas: a case report. Spine. 2011.
7.Liang W, Gao B, Fu P, Xu S, Qian Y, Fu Q. The mirnas in the pathogenesis of osteosarcoma. Front Biosci (Landmark Ed). 2013;18:788鈥?4.View Article
8.He C, Xiong J, Xu X, Lu W, Liu L, Xiao D, et al. Functional elucidation of mir-34 in osteosarcoma cells and primary tumor samples. Biochem Biophys Res Commun. 2009;388:35鈥?0.View Article PubMed
9.Cai CK, Zhao GY, Tian LY, Liu L, Yan K, Ma YL, et al. Mir-15a and mir-16-1 downregulate ccnd1 and induce apoptosis and cell cycle arrest in osteosarcoma. Oncol Rep. 2012;28:1764鈥?0.PubMed
10.Zhu J, Feng Y, Ke Z, Yang Z, Zhou J, Huang X, et al. Down-regulation of mir-183 promotes migration and invasion of osteosarcoma by targeting ezrin. Am J Pathol. 2012;180:2440鈥?1.View Article PubMed
11.Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, et al. Microrna paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Med. 2013;5:2.View Article PubMed Central PubMed
12.Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, et al. Microrna-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther : J Am Soc Gene Ther. 2011;19:1123鈥?0.View Article
13.Zhou X, Wei M, Wang W. Microrna-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting rock1. Biochem Biophys Res Commun. 2013;437:653鈥?.View Article PubMed
14.Yan K, Gao J, Yang T, Ma Q, Qiu X, Fan Q, et al. Microrna-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS One. 2012;7:e33778.View Article PubMed Central PubMed
15.Fan L, Wu Q, Xing X, Wei Y, Shao Z. Microrna-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. Acta Biochim Biophys Sin. 2012;44:407鈥?4.View Article PubMed
16.Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, et al. Paqr3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology. 2013;154:4525鈥?5.View Article PubMed
17.Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, et al. Paqr3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110alpha to the golgi apparatus. Diabetes. 2013;62:444鈥?6.View Article PubMed Central PubMed
18.Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, et al. Rktg inhibits angiogenesis by suppressing mapk-mediated autocrine vegf signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 2010;29:5404鈥?5.View Article PubMed
19.Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, et al. Paqr3 plays a suppressive role in the tumorigenesis of colorectal cancers. Carcinogenesis. 2012;33:2228鈥?5.View Article PubMed
20.Ling ZQ, Guo W, Lu XX, Zhu X, Hong LL, Wang Z, et al. A golgi-specific protein paqr3 is closely associated with the progression, metastasis and prognosis of human gastric cancers. Ann Oncol: Off J Eur Soc Med Oncol / ESMO. 2014;25:1363鈥?2.View Article
21.Wu HG, Zhang WJ, Ding Q, Peng G, Zou ZW, Liu T, et al. Identification of paqr3 as a new candidate tumor suppressor in hepatocellular carcinoma. Oncol Rep. 2014;32:2687鈥?5.PubMed
22.Saldana-Meyer R, Recillas-Targa F. Transcriptional and epigenetic regulation of the p53 tumor suppressor gene. Epigenetics : Off J DNA Methylation Soc. 2011;6:1068鈥?7.View Article
23.Lee SH, Ju SK, Lee TY, Huh SH, Han KH. Tip30 directly binds p53 tumor suppressor protein in vitro. Mol Cells. 2012;34:495鈥?00.View Article PubMed Central PubMed
24.Volodko N, Gordon M, Salla M, Ghazaleh HA, Baksh S: Rassf tumor suppressor gene family: Biological functions and regulation. FEBS Lett. 2014.
25.Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, et al. Mir-152 is a tumor suppressor microrna that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res. 2011;71:6450鈥?2.View Article PubMed
26.Zhang Y, Cai X, Schlegelberger B, Zheng S. Assignment1 of human putative tumor suppressor genes st13 (alias snc6) and st14 (alias snc19) to human chromosome bands 22q13 and 11q24鈥撯€?gt;鈥塹25 by in situ hybridization. Cytogenet Cell Genet. 1998;83:56鈥?.View Article PubMed - 作者单位：Zhiqiang Ma (1)
Yanlong Wang (1)
Taikui Piao (2)
Zhaopeng Li (1)
Hongyu Zhang (1)
Zhixin Liu (1)
Jianyu Liu (1)
1. Department of Orthopedic Surgery, The Second Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150086, People鈥檚 Republic of China
2. Children鈥檚 Hospital of Harbin, Harbin, Heilongjiang Province, 150010, People鈥檚 Republic of China - 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
文摘
Osteosarcoma is the most common primary bone malignancy; however, the molecular mechanisms of development are not well understood. Progestin and AdipoQ receptors (PAQR3), a protein specifically localized in the Golgi apparatus, was recently characterized as a new tumor suppressor. Little is known about the expression and function of PAQR3 in osteosarcoma. Here, we showed that PAQR3 was downregulated in osteosarcoma tissues compared with the adjacent normal regions in 80 paired samples. Moreover, lower levels of PAQR3 were associated with metastasis in clinical osteosarcoma patients. In addition, overexpression of PAQR3 in the osteosarcoma cell line MG-63 inhibited cell proliferation, migration, and invasion by promoting ERK phosphorylation. Taken together, our results indicated that PAQR3 might act as a tumor suppressor in osteosarcoma, providing a novel diagnostic and therapeutic option for human osteosarcoma in the future.