Alteration of mitochondrial function and cell sensitization to death

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• 作者：Vladimir Gogvadze and Boris Zhivotovsky
• 关键词：Mitochondria ; Apoptosis ; Permeability transition ; Cytochrome c ; Cardiolipin
• 刊名：Journal of Bioenergetics and Biomembranes
• 出版年：2007
• 出版时间：February, 2007
• 年：2007
• 卷：39
• 期：1
• 页码：23-30
• 全文大小：241 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Bioorganic Chemistry
  Biochemistry
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  Organic Chemistry
  
• 出版者：Springer New York
• ISSN：1573-6881

文摘

Stimulation of cell death is a powerful instrument in the organism’s struggle with cancer. Apoptosis represents one mode of cell death. However, in a variety of tumor cells proapoptotic mechanisms are downregulated, or not properly activated, whereas antiapoptotic mechanisms are upregulated. Mitochondria are known as key players in the regulation of apoptotic pathways. Specifically, permeabilization of the mitochondrial outer membrane and subsequent release of proapoptotic proteins from the intermembrane space are viewed as decisive events in the initiation and/or execution of apoptosis. Disruption of mitochondrial functions by anticancer drugs, which induce oxidative stress, inhibit mitochondrial respiration, or uncouple oxidative phosphorylation, can sensitize mitochondria in these cells and facilitate outer membrane permeabilization.