Association in a Chinese population of a genetic variation in the early B-cell factor 1 gene with coronary artery disease

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• 作者：Yafei Li ; Zhiyong Xie ; Lei Chen ; Jianjun Yan ; Yao Ma…
• 关键词：Early B ; cell factor 1 ; Genetic polymorphism ; Coronary artery disease ; Risk assessment
• 刊名：BMC Cardiovascular Disorders
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：369KB
• 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2261
• 卷排序：17

文摘

BackgroundEarly B-cell factor 1 (EBF1) is a transcription factor expressed primarily during early B cell development. Previous studies have shown EBF1 regulates blood glucose and lipid metabolism in mice with diabetes and central adiposity. Recently, a genetic variation (rs36071027) located in an EBF1 gene intron was associated with carotid artery intima-media thickness. However, whether this polymorphism is actually linked with coronary artery disease (CAD) and its severity remains unclear.