Relationships between C-reactive protein, white blood cell count, and insulin resistance in a Chinese population

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• 作者：Yu Xu (1)
  Zhiyun Zhao (1)
  Xiaoying Li (1) (2)
  Yufang Bi (1)
  Min Xu (1)
  Guang Ning (1) (2)
  
• 关键词：C ; reactive protein ; White blood cell count ; Insulin resistance
• 刊名：Endocrine
• 出版年：2011
• 出版时间：April 2011
• 年：2011
• 卷：39
• 期：2
• 页码：175-181
• 全文大小：207KB
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• 作者单位：Yu Xu (1)
  Zhiyun Zhao (1)
  Xiaoying Li (1) (2)
  Yufang Bi (1)
  Min Xu (1)
  Guang Ning (1) (2)
  
  1. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, The State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Rui-Jin 2nd Road, Shanghai, 200025, China
  2. The Division of Endocrine and Metabolic Diseases, E-Institute of Shanghai Universities, Shanghai, 200025, China
  

文摘

This study is to clarify whether C-reactive protein (CRP) and white blood cell (WBC) count influence insulin homeostasis to the same degree. Serum CRP and peripheral WBC were measured in 739 subjects with normal glucose regulation, 512 with impaired glucose regulation, and 502 newly diagnosed diabetic patients. Levels of insulin resistance (IR) were assessed using the index of homeostasis model (HOMA-IR). Serum CRP and WBC were significantly correlated with HOMA-IR and risk factors of IR. Relative risks of IR for each 1-SD increase of Ln (CRP) and Ln (WBC) were 1.28 (1.10-.47) and 1.15 (1.01-.31), respectively after adjustment for age, sex, obesity measurements, and other traditional risk factors. Additional adjustment for WBC slightly attenuated the association between CRP and IR [1.25 (1.08-.45); P?=?0.003] whereas adjustment for CRP substantially attenuated the association of WBC with IR toward null (P?=?0.134). Moreover, individuals with both high levels of CRP and WBC were at higher risks of IR than those with high CRP or WBC alone. Both CRP and WBC were significantly associated with risks of IR. CRP might be a more effective biomarker in terms of the association with IR.