Alterations of regional homogeneity in pediatric bipolar depression: a resting-state fMRI study

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• 作者：Weijia Gao ; Qing Jiao ; Shaojia Lu ; Yuan Zhong ; Rongfeng Qi ; Dali Lu…
• 关键词：Pediatric bipolar disorder (PBD) ; Depression episode ; Resting ; fMRI ; Regional homogeneity (ReHo)
• 刊名：BMC Psychiatry
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：1,715 KB
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• 刊物主题：Psychiatry; Psychotherapy;
• 出版者：BioMed Central
• ISSN：1471-244X

文摘

Background Pediatric bipolar disorder (PBD) has attracted increasing attentions due to its high prevalence and great influence on social functions of children and adolescents. However, the pathophysiology underlying PBD remains unclear. In the present study, the resting-state functional magnetic resonance imaging (fMRI) was used to detect abnormalities of baseline brain functions in depressed PBD youth. Methods Seventeen youth with PBD-depression aged 10 - 18?years old and 18 age- and sex-matched normal controls were recruited in this study. The fMRI data under resting state were obtained on a Siemens 3.0 Tesla scanner and were analyzed using the regional homogeneity (ReHo) method. Correlations between the ReHo values of each survived area and the severity of depression symptoms in patients were further analyzed. Results As compared with the control group, PBD-depression patients showed decreased ReHo in the medial frontal gyrus, bilateral middle frontal gyrus and middle temporal gyrus, and the right putamen. Significant negative correlations of the mood and feelings questionnaire scores with mean ReHo values in the medial frontal gyrus and the right middle frontal gyrus in PBD-depression patients were observed. Conclusion Our results suggest that extensive regions with altered baseline brain activities are existed in PBD-depression and these brain regions mainly locate in the fronto-limbic circuit and associated striatal structures. Moreover, the present findings also add to our understanding that there could be unique neuropathophysiological mechanisms underlying PBD-depression.