MiR-690, a Runx2-targeted miRNA, regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65

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• 作者：Shouhe Yu ; Qianqian Geng ; Qiuhui Pan ; Zhongyu Liu ; Shan Ding ; Qi Xiang…
• 关键词：Runx2 ; miR ; 690 ; Osteogenic differentiation ; p65 ; NF ; κB pathway
• 刊名：Cell & Bioscience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：1
• 全文大小：4,165 KB
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• 作者单位：Shouhe Yu (1)
  Qianqian Geng (1)
  Qiuhui Pan (2)
  Zhongyu Liu (3)
  Shan Ding (4)
  Qi Xiang (1)
  Fenyong Sun (5)
  Can Wang (6)
  Yadong Huang (1)
  An Hong (1)
  
  1. Institute of Biomedicine, Jinan University, National Engineering Research Center of Genetic Medicine, Key Lab for Bioengineering Medicine of Guangdong Province, Guangzhou, Guangdong, People’s Republic of China
  2. Central Laboratory, People’s 10th Hospital, Shanghai, People’s Republic of China
  3. College of Life Science, Yangtze University, Jingzhou, Hubei, People’s Republic of China
  4. Department of Materials Science and Engineering, Jinan University, Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou, Guangdong, People’s Republic of China
  5. Department of Medical Laboratory, People’s 10th Hospital, Shanghai, People’s Republic of China
  6. College of Pharmacy, Jinan University, Guangzhou, Guangdong, People’s Republic of China
  
• 刊物主题：Cell Biology; Microbiology;
• 出版者：BioMed Central
• ISSN：2045-3701

文摘

Background The runt-related transcription factor 2 (Runx2) is a cell-fate-determining factor that controls osteoblast differentiation and bone formation. It has been previously demonstrated that microRNAs (miRNAs) play important roles in osteogenesis. However, the Runx2-regulated miRNAs that have been reported thus far are limited. In this study, we pursued to identify these miRNAs in Tet-on stable C2C12 cell line (C2C12/Runx2Dox subline).