Loss of nuclear localization of TET2 in colorectal cancer

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• 作者：Yuji Huang ; Guanghui Wang ; Zhonglin Liang ; Yili Yang ; Long Cui…
• 关键词：TET2 ; Colorectal cancer ; 5hmC ; DNA methylation ; Nuclear localization
• 刊名：Clinical Epigenetics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：8
• 期：1
• 全文大小：957 KB
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• 作者单位：Yuji Huang (1) (2)
  Guanghui Wang (1) (2)
  Zhonglin Liang (1) (2)
  Yili Yang (1) (2)
  Long Cui (1) (2)
  Chen-Ying Liu (1) (2)
  
  1. Department of colorectal and anal surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  2. Shanghai Colorectal Cancer Research Centre, Shanghai, China
  
• 刊物主题：Human Genetics; Gene Function;
• 出版者：BioMed Central
• ISSN：1868-7083

文摘

5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer. Keywords TET2 Colorectal cancer 5hmC DNA methylation Nuclear localization