Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms

详细信息    查看全文

• 作者：Zhongwei Jia (18) (19)
  Shiming Cheng (20)
  Yan Ma (21)
  Tianhao Zhang (22)
  Liqiong Bai (23)
  Weiguo Xu (24)
  Xiaoxin He (22)
  Peiru Zhang (25)
  Jinkou Zhao (24)
  David C Christiani (26)
  
• 关键词：Tuberculosis ; Household contact ; Index cases
• 刊名：BMC Infectious Diseases
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：207 KB
• 作者单位：Zhongwei Jia (18) (19)
  Shiming Cheng (20)
  Yan Ma (21)
  Tianhao Zhang (22)
  Liqiong Bai (23)
  Weiguo Xu (24)
  Xiaoxin He (22)
  Peiru Zhang (25)
  Jinkou Zhao (24)
  David C Christiani (26)
  
  18. National Institute of Drug Dependence, Peking University, Beijing, 100191, China
  19. Takemi Program in International Health, Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA
  20. National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100017, China
  21. Center office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, China
  22. Beijing Research Institute for Tuberculosis Control, Beijing, 100035, China
  23. Hunan institute for Tuberculosis Control, Changsha, 410013, China
  24. Jiangsu Center for Disease Control and Prevention, Nanjing, 210009, China
  25. Sichuan Center for Disease Control and Prevention, Chengdu, 610041, China
  26. Department of Environment health, Harvard School of Public Health, Boston, MA, USA
  
• ISSN：1471-2334

文摘

Background In the context of decreasing tuberculosis prevalence in China, we examined the effectiveness of screening household contacts of tuberculosis patients. Methods A tuberculosis survey was conducted in 2008. All 3,355 household contacts of notified tuberculosis cases were examined with a questionnaire interview, chest X-ray and three sputum smear tests. The effectiveness was examined by comparing the prevalence of pulmonary tuberculosis in household contacts with or without presenting clinical symptoms against the respective notification rates. Regression models were used to evaluate the factors associated with pulmonary tuberculosis. Results Of the 3,355 household contacts, 92 members (2.7%) had pulmonary tuberculosis, among which 46 cases were asymptomatic. The prevalence of pulmonary tuberculosis and smear positive cases in household contacts without symptoms were 20 and 7 times higher than the notification rates in 2008, while those in household contacts with symptoms were 247 and 108 times higher than notification rates, respectively. The patients detected were mainly Index Cases-spouses, sisters/brothers and those who were in contact with female Index Cases. Conclusions The present study provides convincing evidence that household contacts of notified tuberculosis cases are at higher risk of developing tuberculosis. Routine screening for household contacts without any symptoms is recommended for sustained tuberculosis control in China as well as in the world.