Protective effects of oyster extract against hepatic tissue injury in alcoholic liver diseases

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• 作者：Cuiping Zhang (1)
  Xiaoyu Li (1)
  Xue Jing (1)
  Bo Zhang (1)
  Qi Zhang (1)
  Qinghui Niu (1)
  Jianjun Wang (1)
  Zibin Tian (1)
  
• 关键词：oyster extract ; liver diseases ; alcohol ; lipid peroxidation
• 刊名：Journal of Ocean University of China
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：13
• 期：2
• 页码：262-270
• 全文大小：578 KB
• 作者单位：Cuiping Zhang (1)
  Xiaoyu Li (1)
  Xue Jing (1)
  Bo Zhang (1)
  Qi Zhang (1)
  Qinghui Niu (1)
  Jianjun Wang (1)
  Zibin Tian (1)
  
  1. Department of Digestive Diseases, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, P. R. China
  
• ISSN：1993-5021

文摘

Oyster extract is an effective bioactivity component. It has abundant nutritional value and antiviral, antitumor and immune defense functions. The role of oyster extract in treating liver injury has been paid more attention. We use Wistar rats to make alcoholic liver disease model through injecting alcohol into rats-stomachs. These rats were randomly divided into five groups: model group, control group, low-dose, middle-dose and high-dose experimental group with a dose of 0.12 g kg?, 0.40 g kg?, and 1.20 g kg? alcoholic. After nine weeks, serum biomarkers (ALT, AST, TG and TCHO), malondialdehyde (MDA), glutathione (GSH), C3a, C5a, IL-17, TNF-α, anti-MAA-HAS IgG, CD3+, CD4+, CD8+, NK cell activation and zinc content were assessed. The results showed that the serum biomarkers(ALT, AST, TG and TCHO), MDA content, anti-MAA-HSA IgG, serum C3a, C5a IL-17 and TNF-α levels of oyster extract treatment groups were significantly decreased in comparison with model group. On the contrary, GSH showed adverse trend. Serum CD3+, CD4+ and NK cell activation were significantly increased in middle-dose group and high-dose group compared with model group, and there was decrease of CD8+ activity in high-dose group. Plasma Zn level was decreased in model group compared with that in control group. Meanwhile, Mean plasma Zn levels increased dramatically following the dose increase of a given oyster extract.