Perinatal transmission of human papilomavirus DNA

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• 作者：Renato L Rombaldi (1) (3) (4)
  Eduardo P Serafini (2) (3)
  Jovana Mandelli (1)
  Edineia Zimmermann (1)
  Kamille P Losquiavo (1)
  
• 刊名：Virology Journal
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：6
• 期：1
• 全文大小：255KB
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• 作者单位：Renato L Rombaldi (1) (3) (4)
  Eduardo P Serafini (2) (3)
  Jovana Mandelli (1)
  Edineia Zimmermann (1)
  Kamille P Losquiavo (1)
  
  1. Diagnosis 鈥?Molecular Laboratory, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil
  3. Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil
  4. Outpatient Clinic of Genital Pathology, Department of Clinical Medicine, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil
  2. Pathology Medical Laboratory, Department of Health and Biomedical Science, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil
  
• ISSN：1743-422X

文摘

The purpose was to study the perinatal transmission of human papillomavirus DNA (HPV-DNA) in 63 mother-newborn pairs, besides looking at the epidemiological factors involved in the viral DNA transmission. The following sampling methods were used: (1) in the pregnant woman, when was recruited, in cervix and clinical lesions of the vagina, vulva and perineal region; (2) in the newborn, (a) buccal, axillary and inguinal regions; (b) nasopharyngeal aspirate, and (c) cord blood; (3) in the children, buccal was repeated in the 4th week and 6th and 12th month of life. HPV-DNA was identified using two methodologies: multiplex PCR (PGMY09 and MY11 primers) and nested-PCR (genotypes 6/11, 16, 18, 31, 33, 42, 52 and 58). Perinatal transmission was considered when concordance was found in type-specific HPV between mother/newborn or mother/child. HPV-DNA genital was detected in 49 pregnant women submitted to delivery. Eleven newborns (22.4%, n = 11/49) were HPV-DNA positive. In 8 cases (16.3%, n = 8/49) there was type specific HPV concordance between mother/newborn samples. At the end of the first month of life three children (6.1%, n = 3/49) became HPV-DNA positive, while two remained positive from birth. In 3 cases (100%, n = 3/3) there was type specific HPV concordance between mother/newborn samples. In the 6th month, a child (2%, n = 1/49) had become HPV-DNA positive between the 1st and 6th month of life, and there was type specific HPV concordance of mother/newborn samples. All the HPV-DNA positive children (22.4%, n = 11/49) at birth and at the end first month of life (6.1%, n = 3/49) became HPV-DNA negative at the age of 6 months. The HPV-DNA positive child (2%, n = 1/49) from 1st to the 6th month of life became HPV-DNA negative between the 6th and 12th month of life and one child had anogenital warts. In the twelfth month all (100%, n = 49/49) the children studied were HPV-DNA negative. A positive and significant correlation was observed between perinatal transmission of HPV-DNA and the immunodepression of maternal variables (HIV, p = 0.007). Finally, the study suggests that perinatal transmission of HPV-DNA occurred in 24.5% (n = 12/49) of the cases studied.